The colocalization transition of homologous chromosomes at meiosis
Nicodemi, Mario, Panning, Barbara and Prisco, Antonella. (2008) The colocalization transition of homologous chromosomes at meiosis. Physical Review E, Vol.77 (No.6 Part 1). ISSN 1539-3755Full text not available from this repository.
Official URL: http://dx.doi.org/10.1103/PhysRevE.77.061913
Meiosis is the specialized cell division required in sexual reproduction. During its early stages, in the mother cell nucleus, homologous chromosomes recognize each other and colocalize in a crucial step that remains one of the most mysterious of meiosis. Starting from recent discoveries on the system molecular components and interactions, we discuss a statistical mechanics model of chromosome early pairing. Binding molecules mediate long-distance interaction of special DNA recognition sequences and, if their concentration exceeds a critical threshold, they induce a spontaneous colocalization transition of chromosomes, otherwise independently diffusing.
|Item Type:||Journal Article|
|Subjects:||Q Science > QC Physics
Q Science > QH Natural history > QH301 Biology
|Divisions:||Faculty of Science > Physics|
|Library of Congress Subject Headings (LCSH):||Fluorescence microscopy, Homology (Biology), Chromosomes, Meiosis, Statistical mechanics|
|Journal or Publication Title:||Physical Review E|
|Publisher:||American Physical Society|
|Official Date:||June 2008|
|Number:||No.6 Part 1|
|Number of Pages:||4|
|Access rights to Published version:||Restricted or Subscription Access|
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