Management of hypertension in peripheral arterial disease : does the choice of drugs matter?
Singer, Donald R. J. and Kite, A.. (2008) Management of hypertension in peripheral arterial disease : does the choice of drugs matter? European Journal of Vascular and Endovascular Surgery, Vol.35 (No.6). pp. 701-708. ISSN 1078-5884Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.ejvs.2008.01.007
Cardiovascular disease and death are major life-threatening problems in patients with atheromatous peripheral arterial disease (PAD). This review focuses on management of hypertension in the context Of cardiovascular risk in patients with PAD. PAD is underdiagnosed and hypertension in PAD is often poorly managed. Current evidence supports a low threshold for blood pressure treatment in PAD and intensive blood pressure control to reduce the high risk of cardiovascular disease and death in patients with PAD. Optimal treatment targets should be < 140185 mmHg, with the lower target of < 130/80 mmHg in the presence of diabetes mellitus or chronic renal disease. Class-specific selection of anti-hypertensive treatments in PAD should be based on caution in relation to co-existing renovascular disease and indications and contraindications based on other significant co-morbidity. There is a pressing need for primary end-point studies targeted specifically at patients with PAD. In particular, prospective studies in PAD are needed to obtain evidence for benefits from specific blood pressure classes of treatment as well as the optimal blood pressure treatment target level. These studies should consider impact in PAD of different demographic, risk factor, and co-morbidity profiles. (c) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine|
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Hypertension -- Treatment, Peripheral vascular diseases -- Risk factors, Cardiovascular system -- Diseases -- Risk factors|
|Journal or Publication Title:||European Journal of Vascular and Endovascular Surgery|
|Official Date:||June 2008|
|Number of Pages:||8|
|Page Range:||pp. 701-708|
|Access rights to Published version:||Restricted or Subscription Access|
1 LIP GY, MAKIN AJ. Treatment of hypertension in peripheral
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