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Minimally invasive spatial and temporal concentration profiling within working glucose biosensors
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Burt, David P. and Unwin, Patrick R. (2008) Minimally invasive spatial and temporal concentration profiling within working glucose biosensors. Electrochemistry Communications, Vol.10 (No.6). pp. 934-937. doi:10.1016/j.elecom.2008.04.019
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Official URL: http://dx.doi.org/10.1016/j.elecom.2008.04.019
Abstract
The time-dependent evolution of analyte during the operation of working glucose biosensors has been profiled using a carbon fibre microelectrode (CFE). A simple procedure for the fabrication of minimally invasive CFE probes (<8 mu m maximum diameter) is described. By positioning the CFE at well-defined distances from a working biosensor surface it has been possible to track the concentration of ferrocyanide, generated in the enzymatic assay for glucose, as a function of space and time. The results indicate that on the timescale of operation of typical glucose biosensors, the enzyme-mediated oxidation of glucose only occurs to a significant extent in a thin layer close to the sensor surface. In much of the analyte volume the reaction is negligible, contrary to present consensus. (C) 2008 Elsevier B.V. All rights reserved.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Biosensors, Gluscose, Ultramicroelectrodes, Scanning electrochemical microscopy | ||||
| Journal or Publication Title: | Electrochemistry Communications | ||||
| Publisher: | Elsevier Inc. | ||||
| ISSN: | 1388-2481 | ||||
| Official Date: | June 2008 | ||||
| Dates: |
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| Volume: | Vol.10 | ||||
| Number: | No.6 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 934-937 | ||||
| DOI: | 10.1016/j.elecom.2008.04.019 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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