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Elevated concentrations of retinol-binding protein-4 (RBP-4) in gestational diabetes mellitus : negative correlation with soluble vascular cell adhesion molecule-1 (sVCAM-1)
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Lewandowski, Krzysztof C., Stojanovic, Nemanja, Bienkiewicz, Malgorzata, Tan, Bee K., Prelevic, Gordana M., Press, Martin, Tuck, Susan, O'Hare, J. Paul and Randeva, Harpal S. (2008) Elevated concentrations of retinol-binding protein-4 (RBP-4) in gestational diabetes mellitus : negative correlation with soluble vascular cell adhesion molecule-1 (sVCAM-1). Gynecological Endocrinology, Vol.24 (No.6). pp. 300-305. doi:10.1080/09513590802141052 ISSN 0951-3590.
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Official URL: http://dx.doi.org/10.1080/09513590802141052
Abstract
Background. Retinol-binding protein-4 (RBP-4) may increase insulin resistance (IR) in animals, with elevated levels reported in humans with obesity and type 2 diabetes. There are, however, few data on concentrations of RBP-4 in gestational diabetes mellitus (GDM).
Methods. We measured fasting serum levels of RBP-4, soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in 50 women at 28 weeks of gestation, divided according to the results of a 50g glucose challenge test (GCT) and a 75g oral glucose tolerance test (OGTT): (1) controls (n=20), normal responses to both GCT and OGTT; (2) intermediate group (IG) (n=15): false positive GCT, but normal OGTT; and (3) GDM group (n=15), both GCT and OGTT abnormal. IR was assessed by homeostasis model assessment (HOMA-IR) and by insulin resistance index (IRI) based on glycemia and insulinemia during OGTT.
Results. All groups were matched for age and body mass index (BMI). RBP-4 levels (g/ml, meanstandard deviation) were higher in women with GDM vs. controls (53.917.9 vs. 29.713.9, p0.001), with a trend towards higher RBP-4 in GDM compared with IG (38.019.3, p=0.07). There was no significant correlation between RBP-4 and age, BMI, insulin, IRI or HOMA-IR, but there was a moderate, significant negative correlation between RBP-4 and sVCAM-1 (r2=0.20, p=0.001).
Conclusions. RBP-4 levels are elevated in women with GDM, but do not correlate with IR indices and correlate negatively with sVCAM-1. The physiological significance of RBP-4 rise in women with GDM remains to be elucidated.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine R Medicine > RG Gynecology and obstetrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Gynecological Endocrinology | ||||
Publisher: | Informa Healthcare | ||||
ISSN: | 0951-3590 | ||||
Official Date: | 2008 | ||||
Dates: |
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Volume: | Vol.24 | ||||
Number: | No.6 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 300-305 | ||||
DOI: | 10.1080/09513590802141052 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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