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Spatio-temporal modelling explains the effect of reduced plasma membrane Ca2+ efflux on intracellular Ca2+ oscillations in hepatocytes
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Marhl, Marko, Gosak, Marko, Perc, Matjaz, Dixon, C. Jane and Green, Anne K.. (2008) Spatio-temporal modelling explains the effect of reduced plasma membrane Ca2+ efflux on intracellular Ca2+ oscillations in hepatocytes. Journal of Theoretical Biology, Vol.252 (No.3). pp. 419-426. ISSN 0022-5193
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Official URL: http://dx.doi.org/10.1016/j.jtbi.2007.11.006
Abstract
In many non-excitable eukaryotic cells, including hepatocytes, Ca2+ oscillations play a key role in intra- and intercellular signalling, thus regulating many cellular processes from fertilisation to death. Therefore, Understanding the mechanisms underlying these oscillations, and consequently understanding how they may be regulated, is of great interest. In this paper, we study the influence of reduced Ca2+ plasma membrane efflux on Ca2+ oscillations in hepatocytes. Our previous experiments with carboxyeosin show that a reduced plasma membrane Ca2+ efflux increases the frequency of Ca2+ oscillations, but does not affect the duration of individual transients. This phenomenon can be best explained by taking into account not only the temporal, but also the spatial dynamics underlying the generation of Ca2+ oscillations in the cell. Here we divide the cell into a grid of elements and treat the Ca2+ dynamics as a spatio-temporal phenomenon. By converting an existing temporal model into a spatio-temporal one, we obtain theoretical predictions that are in much better agreement with the experimental observations. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology |
| Divisions: | Faculty of Medicine > Warwick Medical School > Education Development and Research Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Intracellular calcium, Oscillating chemical reactions, Liver cells, Cell membranes |
| Journal or Publication Title: | Journal of Theoretical Biology |
| Publisher: | Academic Press |
| ISSN: | 0022-5193 |
| Date: | 7 June 2008 |
| Volume: | Vol.252 |
| Number: | No.3 |
| Number of Pages: | 8 |
| Page Range: | pp. 419-426 |
| Identification Number: | 10.1016/j.jtbi.2007.11.006 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/29874 |
Data sourced from Thomson Reuters' Web of Knowledge
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