Additional contribution of emerging risk factors to the prediction of the risk of type 2 diabetes : evidence from the Western New York Study
Stranges, Saverio, Rafalson, Lisa B., Dmochowski, Jacek, Rejman, Karol, Tracy, Russell P., Trevisan, Maurizio and Donahue, Richard P.. (2008) Additional contribution of emerging risk factors to the prediction of the risk of type 2 diabetes : evidence from the Western New York Study. Obesity, Vol.16 (No.6). pp. 1370-1376. ISSN 1930-7381Full text not available from this repository.
Official URL: http://dx.doi.org/10.1038/oby.2008.59
Objective: To examine whether several biomarkers of endothelial function and inflammation improve prediction of type 2 diabetes over 5.9 years of follow-up, independent of traditional risk factors.
Methods and Procedures: A total of 1,455 participants from the Western New York Study, free of type 2 diabetes at baseline, were selected. Incident type 2 diabetes was defined as fasting glucose exceeding 125 mg/dl or on antidiabetic medication at the follow-up visit. Sixty-one people who met the case definition ( 8/1,000 person years) were identified and individually matched with up to three controls on gender, race, year of study enrollment, and baseline fasting glucose (<110 or 110-125 mg/dl). Biomarkers were measured from frozen baseline samples.
Results: In conditional logistic regression analyses accounting for traditional risk factors ( age, family history of diabetes, smoking, drinking status, and BMI), E-selectin was positively related (3rd vs. 1st tertile: odds ratio 2.77, 95% confidence interval (CI) 1.13-6.79, P for linear trend = 0.023) and serum albumin was inversely related ( 3rd vs. 1st tertile: odds ratio 0.36, 95% CI 0.14-0.93, P for linear trend = 0.032) to type 2 diabetes incidence. The addition of E-selectin, serum albumin, and leukocyte count to a basic risk factor model including only traditional risk factors significantly increased the area under the receiver operating characteristic curve (AUC) ( from 0.646 to 0.726, P value = 0.04).
Discussion: These results support the role of endothelial dysfunction and subclinical inflammation as important mechanisms in the etiopathogenesis of type 2 diabetes; moreover, they indicate that novel biomarkers may improve the prediction of type 2 diabetes beyond the use of traditional risk factors alone.
|Item Type:||Journal Article|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Non-insulin-dependent diabetes -- Pathogenesis -- Research, Non-insulin-dependent diabetes -- Risk factors -- Research, Non-insulin-dependent diabetes -- Prevention -- Research, Biochemical markers|
|Journal or Publication Title:||Obesity|
|Publisher:||Nature Publishing Group|
|Official Date:||June 2008|
|Number of Pages:||7|
|Page Range:||pp. 1370-1376|
|Access rights to Published version:||Restricted or Subscription Access|
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