House, Thomas A. and Keeling, Matthew James. (2008) Deterministic epidemic models with explicit household structure. Mathematical Biosciences, Vol.213 (No.1). pp. 29-39. ISSN 0025-5564

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Abstract

For a wide range of airborne infectious diseases, transmission within the family or household is a key mechanism for the spread and persistence of infection. In general, household-based transmission is relatively strong but only involves a limited number of individuals in contact with each infectious person. In contrast, transmission outside the household can be characterised by many contacts but a lower probability of transmission. Here we develop a relatively simple dynamical model that captures these two transmission regimes. We compare the dynamics of such models for a range of household sizes, whilst constraining all models to have equal early growth rate so that all models fit to the same early incidence observations of an epidemic. Finally we consider the use of prophylactic vaccination, responsive vaccination, or antivirals to combat epidemic spread and focus on whether it is optimal to target controls at entire households or to treat individuals independently. (C) 2008 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Science > Mathematics
Library of Congress Subject Headings (LCSH):	Influenza -- Transmission, Immune response -- Mathematical models, Epidemics -- Mathematical models
Journal or Publication Title:	Mathematical Biosciences
Publisher:	Elsevier Science Inc.
ISSN:	0025-5564
Date:	May 2008
Volume:	Vol.213
Number:	No.1
Number of Pages:	11
Page Range:	pp. 29-39
Identification Number:	10.1016/j.mbs.2008.01.011
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Sixth Framework Programme (European Commission) (FP6)
Grant number:	513715 (FP6)
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URI:	http://wrap.warwick.ac.uk/id/eprint/29939

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