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Calculation of disease dynamics in a population of households
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Ross, Joshua V., House, Thomas A. and Keeling, Matthew James. (2010) Calculation of disease dynamics in a population of households. PLoS One, Vol.5 (No.3). Article no. e9666. ISSN 19326203
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Official URL: http://dx.doi.org/10.1371/journal.pone.0009666
Abstract
Early mathematical representations of infectious disease dynamics assumed a single, large, homogeneously mixing population. Over the past decade there has been growing interest in models consisting of multiple smaller subpopulations (households, workplaces, schools, communities), with the natural assumption of strong homogeneous mixing within each subpopulation, and weaker transmission between subpopulations. Here we consider a model of SIRS (susceptibleinfectiousrecoveredsusceptible) infection dynamics in a very large (assumed infinite) population of households, with the simplifying assumption that each household is of the same size (although all methods may be extended to a population with a heterogeneous distribution of household sizes). For this households model we present efficient methods for studying several quantities of epidemiological interest: (i) the threshold for invasion; (ii) the early growth rate; (iii) the household offspring distribution; (iv) the endemic prevalence of infection; and (v) the transient dynamics of the process. We utilize these methods to explore a wide region of parameter space appropriate for human infectious diseases. We then extend these results to consider the effects of more realistic gammadistributed infectious periods. We discuss how all these results differ from standard homogeneousmixing models and assess the implications for the invasion, transmission and persistence of infection. The computational efficiency of the methodology presented here will hopefully aid in the parameterisation of structured models and in the evaluation of appropriate responses for future disease outbreaks.
Item Type:  Journal Article  

Subjects:  R Medicine > RA Public aspects of medicine  
Divisions:  Faculty of Science > Life Sciences (2010 ) > Biological Sciences ( 2010) Faculty of Science > Mathematics 

Library of Congress Subject Headings (LCSH):  Households  Great Britain, Communicable diseases  Transmission  Mathematical models, Epidemiology  Research, Disease susceptibility  Research, Medical mapping  
Journal or Publication Title:  PLoS One  
Publisher:  Public Library of Science  
ISSN:  19326203  
Official Date:  18 March 2010  
Dates: 


Volume:  Vol.5  
Number:  No.3  
Number of Pages:  9  
Page Range:  Article no. e9666  
Identification Number:  10.1371/journal.pone.0009666  
Status:  Peer Reviewed  
Access rights to Published version:  Open Access  
Funder:  Medical Research Council (Great Britain) (MRC), Wellcome Trust (London, England)  
Grant number:  G0701256 (MRC)  
References:  1. Kermack W, McKendrick A (1927) A contribution to the mathematical theory 

URI:  http://wrap.warwick.ac.uk/id/eprint/2994 
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