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A thermodynamic switch for chromosome colocalization
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Nicodemi, Mario, Panning, Barbara and Prisco, Antonella (2008) A thermodynamic switch for chromosome colocalization. Genetics, Vol.179 (No.1). pp. 717-721. doi:10.1534/genetics.107.083154
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Official URL: http://dx.doi.org/10.1534/genetics.107.083154
Abstract
A general model for the early recognition and colocalization of homologous DNA sequences is proposed. We show, on thermodynamic grounds, how the distance between two homologous DNA sequences is spontaneously regulated by the concentration and affinity of diffusible mediators binding them, which act as a switch between two phases corresponding to independence or colocalization of pairing regions.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH426 Genetics | ||||
| Divisions: | Faculty of Science > Centre for Complexity Science | ||||
| Library of Congress Subject Headings (LCSH): | Fluorescence microscopy, Chromosomes, Chromosomes -- Analysis, Thermodynamics, Nucleotide sequence | ||||
| Journal or Publication Title: | Genetics | ||||
| Publisher: | Genetics Society of America | ||||
| ISSN: | 0016-6731 | ||||
| Official Date: | May 2008 | ||||
| Dates: |
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| Volume: | Vol.179 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 5 | ||||
| Page Range: | pp. 717-721 | ||||
| DOI: | 10.1534/genetics.107.083154 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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