Nicodemi, Mario, Panning, Barbara and Prisco, Antonella. (2008) A thermodynamic switch for chromosome colocalization. Genetics, Vol.179 (No.1). pp. 717-721. ISSN 0016-6731

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Abstract

A general model for the early recognition and colocalization of homologous DNA sequences is proposed. We show, on thermodynamic grounds, how the distance between two homologous DNA sequences is spontaneously regulated by the concentration and affinity of diffusible mediators binding them, which act as a switch between two phases corresponding to independence or colocalization of pairing regions.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH426 Genetics
Divisions:	Faculty of Science > Centre for Complexity Science
Library of Congress Subject Headings (LCSH):	Fluorescence microscopy, Chromosomes, Chromosomes -- Analysis, Thermodynamics, Nucleotide sequence
Journal or Publication Title:	Genetics
Publisher:	Genetics Society of America
ISSN:	0016-6731
Date:	May 2008
Volume:	Vol.179
Number:	No.1
Number of Pages:	5
Page Range:	pp. 717-721
Identification Number:	10.1534/genetics.107.083154
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
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URI:	http://wrap.warwick.ac.uk/id/eprint/29948

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