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Diversity of intrinsic frequency encoding patterns in rat cortical neurons : mechanisms and possible functions
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Kang, Jing, Ph.D., Robinson, Hugh P. C. and Feng, Jianfeng (2010) Diversity of intrinsic frequency encoding patterns in rat cortical neurons : mechanisms and possible functions. PLoS One, Vol.5 (No.3). e9608. doi:10.1371/journal.pone.0009608 ISSN 1932-6203.
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Official URL: http://dx.doi.org/10.1371/journal.pone.0009608
Abstract
Extracellular recordings of single neurons in primary and secondary somatosensory cortices of monkeys in vivo have shown that their firing rate can increase, decrease, or remain constant in different cells, as the external stimulus frequency increases. We observed similar intrinsic firing patterns (increasing, decreasing or constant) in rat somatosensory cortex in vitro, when stimulated with oscillatory input using conductance injection (dynamic clamp). The underlying mechanism of this observation is not obvious, and presents a challenge for mathematical modelling. We propose a simple principle for describing this phenomenon using a leaky integrate-and-fire model with sinusoidal input, an intrinsic oscillation and Poisson noise. Additional enhancement of the gain of encoding could be achieved by local network connections amongst diverse intrinsic response patterns. Our work sheds light on the possible cellular and network mechanisms underlying these opposing neuronal responses, which serve to enhance signal detection.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QL Zoology Q Science > QA Mathematics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Centre for Scientific Computing Faculty of Science, Engineering and Medicine > Science > Computer Science Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC) |
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Library of Congress Subject Headings (LCSH): | Neurons -- Mathematical models, Rats -- Physiology -- Mathematical models, Brain -- Mathematical models | ||||
Journal or Publication Title: | PLoS One | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1932-6203 | ||||
Official Date: | 19 March 2010 | ||||
Dates: |
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Volume: | Vol.5 | ||||
Number: | No.3 | ||||
Page Range: | e9608 | ||||
DOI: | 10.1371/journal.pone.0009608 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Sixth Framework Programme (European Commission) (FP6), University of Warwick, Institute of Advanced Studies (IAS) | ||||
Grant number: | 012788 (SFP) |
Data sourced from Thomson Reuters' Web of Knowledge
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