Ladwa, Sweta R., Dilly, Suzanne J., Clark, A. J. (Andrew J.), Marsh, A. (Andrew) and Taylor, Paul C.. (2008) Rapid identification of a putative interaction between beta(2)-adrenoreceptor agonists and ATF4 using a chemical genomics approach. ChemMedChem, Vol.3 (No.5). pp. 742-744. ISSN 1860-7179

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Abstract

Chemical genomics. We have uncovered a specific interaction between the β2-adrenoreceptor agonist salbutamol and the DNA binding region of transcription factor ATF4 in a chemical genomics approach using phage display combined with photoimmobilisation.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH426 Genetics Q Science > QP Physiology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Chemogenomics, Bacteriophages, Beta adrenoceptors, Transcription factors
Journal or Publication Title:	ChemMedChem
Publisher:	Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:	1860-7179
Date:	19 May 2008
Volume:	Vol.3
Number:	No.5
Number of Pages:	3
Page Range:	pp. 742-744
Identification Number:	10.1002/cmdc.200700317
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
References:	[1] S. R. Salpeter, N. S. Buckley, Clin. Rev. Allergy Immunol. 2006, 31, 219–230; S. G. Rasmussen, H. J. Choi, D. M. Rosebaum, T. S. Kobilka, F. S. Thian, P. C. Edwards, M. Burghammer, V. Ratlana, R. Sanishvilli, R. T. Fischetti, G. F. X. Schertler, W. I. Weis, B. K. Kobilka, Nature 2007, 450, 383–387; V. Cherezov, D. M. Rosenbaum, M. A. Hanson, S. G. F. Rasmussen, F. S. Thian, T. S. Kobilka, H. J. Choi, P. Kuhn, W. I. Weis, B. K. Kobilka, R. C. Stevens, Science 2007, 318, 1258–1265. [2] A. Panebra, M. R. Schwarb, C. B. Glinka, S. B. Liggett, Am. J. Physiol. Lung Cell Mol. Physiol. 2007, 293, L453 and references therein. [3] S. J. Dilly, M. J. Bell, A. J. Clark, A. Marsh, R. M. Napier, M. J. Sergeant, A. J. Thompson, P. C. Taylor, Chem. Commun. 2007, 2808–2810. [4] S. J. Dilly, M. P. Beecham, S. P. Brown, J. M. Griffin, A. J. Clark, C. D. Griffin, J. Marshall, R. M. Napier, P. C. Taylor, A. Marsh, Langmuir 2006, 22, 8144. [5] J. E. Bradner, O. M. McPherson, R. Mazitschek, D. Barnes-Seeman, J. P. Shen, J. Dhaliwal, K. E. Stevenson, J. L. Duffner, S. B. Park, D. S. Neuberg, P. Nghiem, S. L. Schreiber, A. N. Koehler, Chem. Biol. 2006, 13, 493. [6] Y. Suzuki, S. Ito, K. Otsuka, E. Iwasahia, M. Nakajima, I. Yamaguchi, Biosci. Biotech. Bioch. 2005, 69, 601–619. [7] L. M. Podust, A. M. Krezel, Y. Kim, J. Biol. Chem. 2001, 276, 505–513. [8] E. F. Pettersen, T. D. Goddard, C. C. Huang, G. S. Couch, D. M. Greenblatt, E. C. Meng, T. E. Ferrin, J. Comput. Chem. 2004, 25, 1605–1612.
URI:	http://wrap.warwick.ac.uk/id/eprint/29999

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