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Synthesis of 1,1-disubstituted tetrahydro-beta-carbolines from 2-methyleneaziridines
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Mumford, Peter M., Shiers, Jason J., Tarver, Gary J., Hayes, Jerome F. and Shipman, Michael (2008) Synthesis of 1,1-disubstituted tetrahydro-beta-carbolines from 2-methyleneaziridines. Tetrahedron Letters, Vol.49 (No.21). pp. 3489-3491. doi:10.1016/j.tetlet.2008.03.095
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Official URL: http://dx.doi.org/10.1016/j.tetlet.2008.03.095
Abstract
Ring opening of indole functionalised methyleneaziridines (3a-c, 7) with alcohols in the presence of boron trifluoride etherate leads to the formation of 1,1-disubstituted tetrahydro-beta-carbolines in moderate to good yields (37-83%). (c) 2008 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Heterocyclic compounds, Ring-opening polymerization, Aziridines | ||||
| Journal or Publication Title: | Tetrahedron Letters | ||||
| Publisher: | Pergamon | ||||
| ISSN: | 00404039 | ||||
| Official Date: | 19 May 2008 | ||||
| Dates: |
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| Volume: | Vol.49 | ||||
| Number: | No.21 | ||||
| Number of Pages: | 3 | ||||
| Page Range: | pp. 3489-3491 | ||||
| DOI: | 10.1016/j.tetlet.2008.03.095 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Organon (Firm), GlaxoSmithKline | ||||
| Grant number: | BBSSL-200512206 (BBSRC) |
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