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Synthesis of 1,1-disubstituted tetrahydro-beta-carbolines from 2-methyleneaziridines

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Mumford, Peter M., Shiers, Jason J., Tarver, Gary J., Hayes, Jerome F. and Shipman, Michael (2008) Synthesis of 1,1-disubstituted tetrahydro-beta-carbolines from 2-methyleneaziridines. Tetrahedron Letters, Vol.49 (No.21). pp. 3489-3491. doi:10.1016/j.tetlet.2008.03.095

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Official URL: http://dx.doi.org/10.1016/j.tetlet.2008.03.095

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Abstract

Ring opening of indole functionalised methyleneaziridines (3a-c, 7) with alcohols in the presence of boron trifluoride etherate leads to the formation of 1,1-disubstituted tetrahydro-beta-carbolines in moderate to good yields (37-83%). (c) 2008 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Heterocyclic compounds, Ring-opening polymerization, Aziridines
Journal or Publication Title: Tetrahedron Letters
Publisher: Pergamon
ISSN: 00404039
Official Date: 19 May 2008
Dates:
DateEvent
19 May 2008Published
Volume: Vol.49
Number: No.21
Number of Pages: 3
Page Range: pp. 3489-3491
DOI: 10.1016/j.tetlet.2008.03.095
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Organon (Firm), GlaxoSmithKline
Grant number: BBSSL-200512206 (BBSRC)

Data sourced from Thomson Reuters' Web of Knowledge

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