Dynamic ATP signalling and neural development
Dale, Nicholas (2008) Dynamic ATP signalling and neural development. The Journal of Physiology, Vol.586 (No.10). pp. 2429-2436. ISSN 0022-3751Full text not available from this repository.
Official URL: http://dx.doi.org/10.1113/jphysiol.2008.152207
Purinergic signalling plays a major role in the function of every organ including the brain. A growing body of evidence also suggests that purinergic signalling is important in the development of the retina, cochlea and neocortex. In these three contexts release of ATP through the spontaneous gating of connexin hemichannels in cells, respectively, of the retinal pigment epithelium, Kollicker's organ, and the radial glia triggers waves of intracellular Ca2+ release. In the case of the developing retina and cortex, the released ATP acts to control proliferation of neuronal precursor cells, while in the cochlea it coordinates the spontaneous activity of adjacent hair cells to refine the tonotopic maps in the cochlear nucleus. Recently ATP-derived ADP signalling has been implicated at the very earliest stages of development, notably in triggering the gene expression necessary for formation of the eye. It is now timely to test the extent to which connexin hemichannel-mediated ATP release and accompanying Ca2+ waves contribute to all stages of development.
|Item Type:||Journal Item|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Q Science > QP Physiology
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)|
|Library of Congress Subject Headings (LCSH):||Adenosine triphosphate, Purines -- Receptors, Cellular signal transduction, Developmental neurobiology, Nervous system -- Growth|
|Journal or Publication Title:||The Journal of Physiology|
|Publisher:||Wiley-Blackwell Publishing Ltd.|
|Date:||15 May 2008|
|Number of Pages:||8|
|Page Range:||pp. 2429-2436|
|Access rights to Published version:||Restricted or Subscription Access|
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