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The scale of population structure in Arabidopsis thaliana
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(2010) The scale of population structure in Arabidopsis thaliana. PLoS Genetics, Vol.6 (No.2). e1000843. doi:10.1371/journal.pgen.1000843 ISSN 1553-7390.
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Official URL: http://dx.doi.org/10.1371/journal.pgen.1000843
Abstract
The population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow. Understanding it is a prerequisite for detecting genomic regions under selection, predicting the effect of population disturbances, or modeling gene flow. This paper examines the detailed global population structure of Arabidopsis thaliana. Using a set of 5,707 plants collected from around the globe and genotyped at 149 SNPs, we show that while A. thaliana as a species self-fertilizes 97% of the time, there is considerable variation among local groups. This level of outcrossing greatly limits observed heterozygosity but is sufficient to generate considerable local haplotypic diversity. We also find that in its native Eurasian range A. thaliana exhibits continuous isolation by distance at every geographic scale without natural breaks corresponding to classical notions of populations. By contrast, in North America, where it exists as an exotic species, A. thaliana exhibits little or no population structure at a continental scale but local isolation by distance that extends hundreds of km. This suggests a pattern for the development of isolation by distance that can establish itself shortly after an organism fills a new habitat range. It also raises questions about the general applicability of many standard population genetics models. Any model based on discrete clusters of interchangeable individuals will be an uneasy fit to organisms like A. thaliana which exhibit continuous isolation by distance on many scales.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QK Botany Q Science > QH Natural history > QH426 Genetics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Warwick HRI (2004-2010) | ||||
Library of Congress Subject Headings (LCSH): | Arabidopsis thaliana, Plant population genetics, Plant populations, Fertilization of plants | ||||
Journal or Publication Title: | PLoS Genetics | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1553-7390 | ||||
Official Date: | 12 February 2010 | ||||
Dates: |
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Volume: | Vol.6 | ||||
Number: | No.2 | ||||
Page Range: | e1000843 | ||||
DOI: | 10.1371/journal.pgen.1000843 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | National Science Foundation (U.S.) (NSF), National Institutes of Health (U.S.) (NIH) | ||||
Grant number: | DEB-0519961 (NSF), GM073822 (NIH), GM07994 (NIH), DEB - 0723935 (NSF) |
Data sourced from Thomson Reuters' Web of Knowledge
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