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The scale of population structure in Arabidopsis thaliana

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Platt, A. (Alexander), Horton, Matthew, Huang, Yu S., Li, Y. (Yan), Anastasio, Alison Elizabeth, Mulyati, Ni Wayan, Ågren, Jon, Bossdorf, Oliver, Byers, Diane, Donohue, Kathleen, Ph.D. et al.

. (2010) The scale of population structure in Arabidopsis thaliana. PLoS Genetics, Vol.6 (No.2). e1000843. ISSN 1553-7390

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Official URL: http://dx.doi.org/10.1371/journal.pgen.1000843

Abstract

The population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow. Understanding it is a prerequisite for detecting genomic regions under selection, predicting the effect of population disturbances, or modeling gene flow. This paper examines the detailed global population structure of Arabidopsis thaliana. Using a set of 5,707 plants collected from around the globe and genotyped at 149 SNPs, we show that while A. thaliana as a species self-fertilizes 97% of the time, there is considerable variation among local groups. This level of outcrossing greatly limits observed heterozygosity but is sufficient to generate considerable local haplotypic diversity. We also find that in its native Eurasian range A. thaliana exhibits continuous isolation by distance at every geographic scale without natural breaks corresponding to classical notions of populations. By contrast, in North America, where it exists as an exotic species, A. thaliana exhibits little or no population structure at a continental scale but local isolation by distance that extends hundreds of km. This suggests a pattern for the development of isolation by distance that can establish itself shortly after an organism fills a new habitat range. It also raises questions about the general applicability of many standard population genetics models. Any model based on discrete clusters of interchangeable individuals will be an uneasy fit to organisms like A. thaliana which exhibit continuous isolation by distance on many scales.

Item Type:	Journal Article
Subjects:	Q Science > QK Botany Q Science > QH Natural history > QH426 Genetics
Divisions:	Faculty of Science > Life Sciences (2010- ) > Warwick HRI (2004-2010)
Library of Congress Subject Headings (LCSH):	Arabidopsis thaliana, Plant population genetics, Plant populations, Fertilization of plants
Journal or Publication Title:	PLoS Genetics
Publisher:	Public Library of Science
ISSN:	1553-7390
Date:	12 February 2010
Volume:	Vol.6
Number:	No.2
Page Range:	e1000843
Identification Number:	10.1371/journal.pgen.1000843
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	National Science Foundation (U.S.) (NSF), National Institutes of Health (U.S.) (NIH)
Grant number:	DEB-0519961 (NSF), GM073822 (NIH), GM07994 (NIH), DEB - 0723935 (NSF)
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URI:	http://wrap.warwick.ac.uk/id/eprint/3002