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Paths reunited: initiation of the classical and lectin pathways of complement activation

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Wallis, Russell, Mitchell, Daniel Anthony, Schmid, Ralf, Schwaeble, Wilhelm W. and Keeble, Anthony H.. (2010) Paths reunited: initiation of the classical and lectin pathways of complement activation. Immunobiology, Vol.215 (No.1). pp. 1-11. ISSN 0171-2985

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Official URL: http://dx.doi.org/10.1016/j.imbio.2009.08.006

Abstract

Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago. Nevertheless, knowledge is still incomplete, especially with regard to the interactions between its subcomponents C1q, C1r and C1s that trigger activation upon binding to a microbial target. Recent studies have provided new insights into these interactions, and have revealed unexpected parallels with initiating complexes of the lectin pathway of complement: MBL–MASP and ficolin–MASP. Here, we develop and expand these concepts and delineate their implications towards the key aspects of complement activation via the classical and lectin pathways.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Complement activation, Enzyme activation, Natural immunity -- Research, Lectins -- Research
Journal or Publication Title:	Immunobiology
Publisher:	Elsevier
ISSN:	0171-2985
Date:	January 2010
Volume:	Vol.215
Number:	No.1
Page Range:	pp. 1-11
Identification Number:	10.1016/j.imbio.2009.08.006
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC), Research Councils UK (RCUK)
Grant number:	077400 (Wellcome), G0501425 (MRC)
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URI:	http://wrap.warwick.ac.uk/id/eprint/3007