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Paths reunited: initiation of the classical and lectin pathways of complement activation
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Wallis, Russell, Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J. and Keeble, Anthony H. (2010) Paths reunited: initiation of the classical and lectin pathways of complement activation. Immunobiology, Vol.215 (No.1). pp. 1-11. doi:10.1016/j.imbio.2009.08.006 ISSN 0171-2985.
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Official URL: http://dx.doi.org/10.1016/j.imbio.2009.08.006
Abstract
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago. Nevertheless, knowledge is still incomplete, especially with regard to the interactions between its subcomponents C1q, C1r and C1s that trigger activation upon binding to a microbial target. Recent studies have provided new insights into these interactions, and have revealed unexpected parallels with initiating complexes of the lectin pathway of complement: MBL–MASP and ficolin–MASP. Here, we develop and expand these concepts and delineate their implications towards the key aspects of complement activation via the classical and lectin pathways.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QR Microbiology > QR180 Immunology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Complement activation, Enzyme activation, Natural immunity -- Research, Lectins -- Research | ||||
Journal or Publication Title: | Immunobiology | ||||
Publisher: | Elsevier | ||||
ISSN: | 0171-2985 | ||||
Official Date: | January 2010 | ||||
Dates: |
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Volume: | Vol.215 | ||||
Number: | No.1 | ||||
Page Range: | pp. 1-11 | ||||
DOI: | 10.1016/j.imbio.2009.08.006 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Wellcome Trust (London, England), Medical Research Council (Great Britain) (MRC), Research Councils UK (RCUK) | ||||
Grant number: | 077400 (Wellcome), G0501425 (MRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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