Zammit, Victor A.. (2008) Carnitine palmitoyltransferase 1: Central to cell function. IUBMB Life, Vol.60 (No.5). pp. 347-354. ISSN 1521-6543

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Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology
Divisions:	Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Carnitine, Transferases, Cell physiology
Journal or Publication Title:	IUBMB Life
Publisher:	Wiley-Blackwell Publishing Ltd.
ISSN:	1521-6543
Date:	May 2008
Volume:	Vol.60
Number:	No.5
Number of Pages:	8
Page Range:	pp. 347-354
Identification Number:	10.1002/iub.78
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	British Heart Foundation, Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Diabetes UK, Great Britain. Scottish Office
References:	1. McGarry, J. D., Mannaerts, G. P., and Foster, D. W. (1977) A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J. Clin. Invest. 60, 265–270. 2. McGarry, J. D., Mannaerts, G. P., Foster, and D. W. (1978) Characteristics of fatty acid oxidation in rat liver homogenates and the inhibitory effect of malonyl-CoA. Biochim. Biophys. Acta 530, 305–313. 3. McGarry, J. D., and Brown, N. F. (1997) The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244, 1–14. 4. Saggerson, E. D. (1982) Carnitine acyltransferase activities in rat liver and heart measured with palmitoyl-CoA and octanoyl-CoA—latency, effects of K1, bivalent metal ions and malonyl-CoA. Biochem. J. 202, 397–405. 5. Park, E. A., and Cook, G. A. (1998) Differential regulation in the heart of mitochondrial carnitine palmitoyltransferase-I muscle and liver isoforms. Mol. Cell Biochem. 180, 27–32. 6. Paulson, D. J., Ward, K. M., and Shug, A. L. (1984) Malonyl CoA inhibition of carnitine palmityltransferase in rat heart mitochondria. FEBS Lett. 176, 381–384. 7. Price, N., van der Leij, F., Jackson, V., Corstorphine, C., Thomson, R., Sorensen, A., and Zammit, V. (2002) A novel brain-expressed protein related to carnitine palmitoyltransferase I. Genomics 80, 433–442. 8. Wolfgang, M. J., Kurama, T., Dai, Y., Suwa, A., Asaumi, M., Matsumoto, S., Cha, S. H., Shimokawa, T., and Lane, M. D. (2006) The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc. Natl. Acad. Sci USA 103, 7282–7287. 9. Sierra, A. Y., Gratacos, E., Carrasco, P. Clotet, J., Urena, J., Serra, D., Asins, G., Hegardt, F. G., and Casals, N. (2008) CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. J. Biol. Chem, 283, 6878–6885. 10. Dai, Y., Wolfgang, M. J., Cha, S. H., and Lane, M. D. (2007) Localization and effect of ectopic expression of CPT1c in CNS feeding centers. Biochem. Biophys. Res. Commun. 359, 469–474. 11. Ontko, J. A., and Johns, M. L. (1980) Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system. Biochem. J. 192, 959–962. 12. Cook, G. A., Otto, D. A., and Cornell, N. W. (1980) Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats. Biochem. J. 192, 955–958. 13. Robinson, I. N., and Zammit, V. A. (1982) Sensitivity of carnitine acyltransferase I to malonyl-CoA in isolated rat liver mitochondria is quantitatively related to hepatic malonyl-CoA concentration. Biochem. J. 206, 177–179. 14. Grantham, B. D. and Zammit, V. A. (1986) Restoration of the properties of carnitine palmitoyltransferase I in liver mitochondria during refeeding of starved rats. Biochem. J. 239, 485–488. 15. Grantham, B. D. and Zammit, V. A. (1988) Role of carnitine palmitoyltransferase I in the regulation of hepatic ketogenesis during the onset and reversal of chronic diabetes. Biochem. J. 249, 409–414. 16. Moir, A. M. B. and Zammit, V. A. (1995) Acute meal-induced changes in hepatic glycerolipid metabolism are unimpaired in severely diabetic rats: implications for the role of insulin. FEBS Lett. 370, 255–258. 17. Moir, A. M. B. and Zammit, V. A. (1992) Selective labelling of hepatic fatty acids in vivo. Studies on the synthesis and secretion of glycerolipids in the rat. Biochem. J. 283, 145–149. 18. Moir, A. M. B. and Zammit, V. A. (1993) Rapid switch of hepatic fatty acid metabolism from oxidation to esterification during diurnal feeding of meal-fed rats correlates with changes in the properties of acetyl-CoA carboxylase, but not of carnitine palmitoyl transferase I. Biochem. J. 291, 241–246. 19. Moir, A. M. B., and Zammit, V. A. (1993) Monitoring of changes in hepatic fatty acid and glycerolipid metabolism during the starved-to-fed transition in vivo. Studies on awake, unrestrained rats. Biochem. J. 289, 49–55. 20. Brown, N. F., Esser, V., Foster, D. W., and McGarry, J. D. (1994) Expression of a cDNA for rat liver carnitine palmitoyltransferase I in yeast establishes that catalytic activity and malonyl-CoA sensitivity reside in a single polypeptide. J. Biol. Chem. 269, 26438–26642. 21. Zammit, V. A. (1984) Time-dependence of inhibition of carnitine palmitoyltransferase I by malonyl-CoA in mitochondria isolated from livers of fed or starved rats. Biochem. J. 218, 379–386. 22. Zammit, V. A., Corstorphine, C. G., Kolodziej, M. P., Fraser, F. (1998) Lipid molecular order in liver mitochondrial outer membranes, and sensitivity of carnitine palmitoyltransferase I to malonyl-CoA. Lipids 33, 371–376. 23. Kerner, J. and Bieber, L. (1990) Isolation of a malonyl-CoA-sensitive CPT/b-oxidation enzyme complex from heart mitochondria. Biochemistry 29, 4326–4334. 24. Fraser, F. and Zammit, V. A. (1998) Enrichment of carnitine palmitoyltransferases I and II in the contact sites of rat liver mitochondria. Biochem. J. 329, 225–229. 25. McGarry, J. and Foster, D. W. (1980) Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem. 49, 395– 420. 26. Fraser, F., Corstorphine, C. G., and Zammit, V. A. (1997) Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane. Biochem. J. 323, 711–718. 27. van der Leij, F. R., Kram, A. M., Bartelds, B., Roelofsen, H., Smid, G. B., Takens, J., Zammit, V. A., and Kuipers, J. R. (1999) Cytological evidence that the C-terminus of carnitine palmitoyltransferase I is on the cytosolic face of the mitochondrial outer membrane. Biochem. J. 341, 777–784. 28. Zammit, V. (1999) Carnitine acyltransferases: functional significance of subcellular distribution and membrane topology. Progr. Lipid Res. 38, 199–224. 29. Shi, J., Zhu, H., Arvidson, D. N., and Woldegiorgis, G. (1999) A single amino acid change (substitution of glutamate 3 with alanine) in the Nterminal region of rat liver carnitine palmitoyltransferase I abolishes Malonyl-CoA inhibition and high affinity binding. J. Biol. Chem. 274, 9421–9426. 30. Jackson, V., Price, N., and Zammit, V. (2001) Specificity of the interactions between Glu-3, Ser-24 and Gln-30 within the N-terminal segment of rat liver mitochondrial overt carnitine palmitoyltransferase (L-CPT I) in determining the malonyl-CoA sensitivity of the enzyme. Biochemistry 40, 14629–14634. 31. Jackson, V. N., Cameron, J. M., Fraser, F., Zammit, V. A., and Price, N. T. (2000) Use of six chimeric proteins to investigate the role of intramolecular interactions in determining the kinetics of carnitine palmitoyltransferase I isoforms [in process citation]. J. Biol. Chem. 275, 19560–19566. 32. Jackson, V. N., Zammit, V. A., and Price, N. T. (2000) Identification of positive and negative determinants of malonyl-CoA- sensitivity and carnitine affinity within the amino-termini of rat liver- and muscle-type carnitine palmitoyltransferase I. J. Biol. Chem. 275, 38410–38416. 33. Faye, A., Borthwick, K., Esnous, C., Price, N. T., Gobin, S., Jackson, V. N., Zammit, V. A., Girard, J., and Prip-Buus, C. (2004) Demonstration of N/C intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity. Biochem. J. 237, 123. 34. Morillas, M., Lopez, V. E., Valencia, A., Serra, D., P.Gomez-Puertas, Hegardt, F. G., and Asins, G. (2004) Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal. Biochem. J. 379, 777–784. 35. Lopez-Vinas, E., Bentebibel, A., Gurunathan, C., Morillas, M., de Arriaga, D., Serra, D., Asins, G., Hegardt, F. G., and Gomez-Puertas, P. (2007) Definition by functional and structural analysis of two malonyl- CoA sites in carnitine palmitoyltransferase 1A. J. Biol. Chem. 282, 18212–18224. 36. Borthwick, K., Jackson, V. N., Price, N. T., and Zammit, V. A. (2006) The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity. J. Biol. Chem. 281, 32946–32952. 37. Curran, A. R. and Engelman, D. M. (2003) Sequence motifs, polar interactions and conformational changes in helical membrane proteins. Curr. Opin. Struct. Biol. 13, 412–417. 38. Brandt, J. M., Djouadi, F., and Kelly, D. P. (1998) Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 273, 23786–23792. 39. Kerner, J., Distler, A. M., Minkler, P., Parland, W., Peterman, S. M., and Hoppel, C. L. (2004) Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme. J. Biol. Chem. 279, 41104–41113. 40. Eaton, S., Fukumoto, K., Stefanutti, G., Spitz, L., Zammit, V. A., and Pierro, A. (2003) Myocardial carnitine palmitoyltransferase I as a target for oxidative modification in inflammation and sepsis. Biochem. Soc. Trans. 31, 1133–1136. 41. Fukumoto, K., Pierro, A., Zammit, V. A., Spitz, L., and Eaton, S. (2004) Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats. Biochim. Biophys. Acta 1683, 1–6. 42. Leterrier, J. F., Rusakov, B. D., Nelson, B. D., and Linden, M. (1994) Interactions between brain mitochondria and cytoskeleton: evidence for specialized outer membrane domains involved in the association of cytoskeleton- associated proteins to mitochondria in situ and in vitro. Microsc. Res. Tech. 27, 233–261. 43. Guzman, M., Kolodziej, M. P., Caldwell, A., Corstorphine, C. G., and Zammit, V. A. (1994) Evidence against direct involvement of phosphorylation in the activation of carnitine palmitoyltransferase I by akadaic acid in rat hepatocytes. Biochem. J. 300, 693–699. 44. Guzman, M., Velasco, G., Castro, J., and Zammit, V. A. (1994) Inhibition of carnitine palmitoyltransferase I by hepatocyte swelling. FEBS Lett. 344, 239–241. 45. Ruderman, N. and Prentki, M. (2004) AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat. Rev. Drug Discov. 3, 340–351. 46. Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R., Newgard, C. B., Lopaschuk, G. D., and Muoio, D. M. (2008) Mitochondrial overload and incomplete Fatty Acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7, 45–56. 47. Dobbins, R. L., Szczepaniak, L. S., Bentley, B., Esser, V., Myhill, J., and McGarry, J. D. (2001) Prolonged inhibition of muscle carnitine pal- mitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats.[in process citation]. Diabetes 50, 123–130. 48. Prentki, M. and Corkey, B. E. (1996) Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45, 273–283. 49. Prentki, M., Tornheim, K., and Corkey, B. E. (1997) Signal transduction mechanisms in nutrient-induced insulin secretion. Diabetologia 40, S32–S41. 50. Mountjoy, P. D. and Rutter, G. A. (2007) Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms? Exp. Physiol. 92, 311–319. 51. Lam, T. K., Pocai, A., R.Gutierrez-Juarez, Obici, S., Bryan, J., Aguilar- Bryan, L., Schwartz, G. J., and Rossetti, L. (2005) Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat. Med. 11, 320–327. 52. Pocai, A., Lam, T. K., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., and Rossetti, L. (2005) Hypothalamic K(ATP) channels control hepatic glucose production. Nature 434, 1026–1031. 53. Lam, T. K., Gutierrez-Juarez, R., Pocai, A., Bhanot, S., Tso, P., Schwartz, G. J., and Rossetti, L. (2007) Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nat. Med. 13, 171–180.
URI:	http://wrap.warwick.ac.uk/id/eprint/30114

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