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Spatial simulations of myxobacterial development
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Holmes, Antony, Kalvala, Sara and Whitworth, David E. (2010) Spatial simulations of myxobacterial development. PLoS Computational Biology, Vol.6 (No.2). e1000686. doi:10.1371/journal.pcbi.1000686 ISSN 1553-734X.
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Official URL: http://dx.doi.org/10.1371/journal.pcbi.1000686
Abstract
Understanding how relatively simple, single cell bacteria can communicate and coordinate their actions is important for explaining how complex multicellular behaviour can emerge without a central controller. Myxobacteria are particularly interesting in this respect because cells undergo multiple phases of coordinated behaviour during their life-cycle. One of the most fascinating and complex phases is the formation of fruiting bodies—large multicellular aggregates of cells formed in response to starvation. In this article we use evidence from the latest experimental data to construct a computational model explaining how cells can form fruiting bodies. Both in our model and in nature, cells move together in dense swarms, which collide to form aggregation centres. In particular, we show that it is possible for aggregates to form spontaneously where previous models require artificially induced aggregates to start the fruiting process.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QR Microbiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC) Faculty of Science, Engineering and Medicine > Science > Computer Science |
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Library of Congress Subject Headings (LCSH): | Myxobacterales -- Research, Bacteria -- Motility -- Mathematical models, Spatial analysis (Statistics), Monte Carlo method | ||||
Journal or Publication Title: | PLoS Computational Biology | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1553-734X | ||||
Official Date: | 26 February 2010 | ||||
Dates: |
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Volume: | Vol.6 | ||||
Number: | No.2 | ||||
Number of Pages: | 13 | ||||
Page Range: | e1000686 | ||||
DOI: | 10.1371/journal.pcbi.1000686 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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