Spatial simulations of myxobacterial development
Holmes, Antony, Kalvala, Sara and Whitworth, David E. (2010) Spatial simulations of myxobacterial development. PLoS Computational Biology, Vol.6 (No.2). e1000686. ISSN 1553-734X Official URL: http://dx.doi.org/10.1371/journal.pcbi.1000686 AbstractUnderstanding how relatively simple, single cell bacteria can communicate and coordinate their actions is important for explaining how complex multicellular behaviour can emerge without a central controller. Myxobacteria are particularly interesting in this respect because cells undergo multiple phases of coordinated behaviour during their life-cycle. One of the most fascinating and complex phases is the formation of fruiting bodies—large multicellular aggregates of cells formed in response to starvation. In this article we use evidence from the latest experimental data to construct a computational model explaining how cells can form fruiting bodies. Both in our model and in nature, cells move together in dense swarms, which collide to form aggregation centres. In particular, we show that it is possible for aggregates to form spontaneously where previous models require artificially induced aggregates to start the fruiting process. | Item Type: | Journal Article |
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| Subjects: | Q Science > QR Microbiology |
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| Divisions: | Faculty of Science > Molecular Organisation and Assembly in Cells (MOAC)
Faculty of Science > Computer Science |
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| Library of Congress Subject Headings (LCSH): | Myxobacterales -- Research, Bacteria -- Motility -- Mathematical models, Spatial analysis (Statistics), Monte Carlo method |
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| Journal or Publication Title: | PLoS Computational Biology |
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| Publisher: | Public Library of Science |
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| ISSN: | 1553-734X |
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| Date: | 26 February 2010 |
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| Volume: | Vol.6 |
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| Number: | No.2 |
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| Number of Pages: | 13 |
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| Page Range: | e1000686 |
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| Identification Number: | doi:10.1371/journal.pcbi.1000686 |
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| Status: | Peer Reviewed |
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| Access rights to Published version: | Open Access |
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| Funder: | Engineering and Physical Sciences Research Council (EPSRC) |
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