Genome mining for novel natural product discovery
Challis, Gregory L.. (2008) Genome mining for novel natural product discovery. Journal of Medicinal Chemistry, Vol.51 (No.9). pp. 2618-2628. ISSN 0022-2623Full text not available from this repository.
Official URL: http://dx.doi.org/10.1021/jm700948z
Genomics has resulted in the deposition of a huge quantity
of DNA sequence data from a wide variety of organisms in
publicly accessible databases. Such data can be exploited to
generate new knowledge in several areas relevant to medicinal
chemistry including the characterization of human physiological
processes, the identification and validation of new drug targets
in human pathogens, and the discovery of new chemical entities
(NCEsa) from natural sources, which may form the basis for
new drug leads. The term “genome mining” has been used in
various fields to describe the exploitation of genomic information
for the discovery of new processes, targets, and products.
This Miniperspective will focus on the development of genome
mining approaches for the discovery of new natural products.
It will also discuss future prospects for the application of genome
mining technology to NCE discovery and lead generation.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH426 Genetics
|Divisions:||Faculty of Science > Chemistry|
|Library of Congress Subject Headings (LCSH):||Genomics, Natural products -- Research, Natural products -- Biotechnology|
|Journal or Publication Title:||Journal of Medicinal Chemistry|
|Publisher:||American Chemical Society|
|Official Date:||8 May 2008|
|Number of Pages:||11|
|Page Range:||pp. 2618-2628|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), European Union (EU)|
|Grant number:||B16610 (BBSRC), EGH16081 (BBSRC), 005224 (EU)|
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