Butler, Anthony R. and Feelisch, Martin (2008) Therapeutic uses of inorganic nitrite and nitrate - from the past to the future. Circulation, Vol.117 (No.16). pp. 2151-2159. doi:10.1161/CIRCULATIONAHA.107.753814

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Abstract

Potential carcinogenic effects, blue baby syndrome, and occasional intoxications caused by nitrite, as well as the suspected health risks related to fertilizer overuse, contributed to the negative image that inorganic nitrite and nitrate have had for decades. Recent experimental studies related to the molecular interaction between nitrite and heme proteins in blood and tissues, the potential role of nitrite in hypoxic vasodilatation, and an unexpected protective action of nitrite against ischemia/reperfusion injury, however, paint a different picture and have led to a renewed interest in the physiological and pharmacological properties of nitrite and nitrate. The range of effects reported suggests that these simple oxyanions of nitrogen have a much richer profile of biological actions than hitherto assumed, and several efforts are currently underway to investigate possible beneficial effects in the clinical arena. We provide here a brief historical account of the medical uses of nitrite and nitrate over the centuries that may serve as a basis for a careful reassessment of the health implications of their exposure and intake and may inform investigations into their therapeutic potential in the future.

Item Type:	Journal Item
Subjects:	R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Cardiovascular system -- Diseases -- Treatment, Nitrates -- Therapeutic use, Nitrites -- Therapeutic use, Nitric oxide -- Physiological effect, Nitric oxide -- Therapeutic use
Journal or Publication Title:	Circulation
Publisher:	Lippincott Williams & Wilkins
ISSN:	0009-7322
Official Date:	22 April 2008
Dates:	Date Event 22 April 2008 Published
Volume:	Vol.117
Number:	No.16
Number of Pages:	9
Page Range:	pp. 2151-2159
DOI:	10.1161/CIRCULATIONAHA.107.753814
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Guthrie Trust, Medical Research Council (Great Britain) (MRC)

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