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Metallothioneins with unusual residues : histidines as modulators of zinc affinity and reactivity
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Blindauer, Claudia A. (2008) Metallothioneins with unusual residues : histidines as modulators of zinc affinity and reactivity. In: 1st Georgian Bay International Conference on Bioinorganic Chemistry, Parry Sound, Canada, 22-25 May 2007. Published in: Journal of Inorganic Biochemistry, Vol.102 (No.3). pp. 507-521.
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Official URL: http://dx.doi.org/10.1016/j.jinorgbio.2007.10.032
Abstract
For many years, paradigms regarding metallothioneins comprised the exclusive metal coordination by thiolates from cysteine residues and the absence of aromatic residues. As more sequence and in vitro data on metallothioneins, in particular from non-vertebrate organisms, has become available, both the occurrence of and metal coordination by histidine residues in metallothioneins is emerging as a more frequent feature than expected. We discuss the general implications of histidines versus cysteines in zinc binding sites, and review some recent results from literature and our own lab. We conclude that histidines can stabilise metallothionein clusters by reducing the overall charge, offering the ability to help with structural organisation by supplying H-bond donor and acceptor properties, reducing the likelihood for disulfide bond formation, whilst maintaining a high affinity towards metal ions, in particular the borderline zinc ion. (C) 2007 Elsevier Inc. All rights reserved.
| Item Type: | Conference Item (Paper) |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
| Divisions: | Faculty of Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Zinc, Metallothionein, Bioinorganic chemistry, Amino acids |
| Journal or Publication Title: | Journal of Inorganic Biochemistry |
| Publisher: | Elsevier Science Inc |
| ISSN: | 0162-0134 |
| Date: | March 2008 |
| Volume: | Vol.102 |
| Number: | No.3 |
| Number of Pages: | 15 |
| Page Range: | pp. 507-521 |
| Identification Number: | 10.1016/j.jinorgbio.2007.10.032 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Funder: | Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Swiss National Science Foundation], Novartis Foundation, European Commission (EC), Wellcome Trust (London, England) |
| Conference Paper Type: | Paper |
| Title of Event: | 1st Georgian Bay International Conference on Bioinorganic Chemistry |
| Type of Event: | Conference |
| Location of Event: | Parry Sound, Canada |
| Date(s) of Event: | 22-25 May 2007 |
| URI: | http://wrap.warwick.ac.uk/id/eprint/30326 |
Data sourced from Thomson Reuters' Web of Knowledge
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