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Sensibility of the quorum growth thresholds controlling local immune responses

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Burroughs, Nigel John, Oliveira, B. M. P. M., Pinto, Alberto A. and Sequeira, H. J. T.. (2008) Sensibility of the quorum growth thresholds controlling local immune responses. Mathematical and Computer Modelling, Vol.47 (No.7-8). pp. 714-725. ISSN 0895-7177

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Official URL: http://dx.doi.org/10.1016/j.mcm.2007.06.007

Abstract

The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs. (C) 2007 Elsevier Ltd. All rights reserved.

Item Type:

Journal Article

Subjects:

Q Science > QA Mathematics
Q Science > QR Microbiology > QR180 Immunology

Divisions:

Faculty of Science > Mathematics

Library of Congress Subject Headings (LCSH):

Immunology -- Mathematical models, T cells, Immune response -- Regulation, Cytokines -- Secretion

Journal or Publication Title:

Mathematical and Computer Modelling

Publisher:

Pergamon

ISSN:

0895-7177

Official Date:

April 2008

Dates:

Date	Event
April 2008	Published

Volume:

Vol.47

Number:

No.7-8

Number of Pages:

Page Range:

pp. 714-725

Identification Number:

10.1016/j.mcm.2007.06.007

Status:

Peer Reviewed

Publication Status:

Published

Access rights to Published version:

Restricted or Subscription Access

Funder:

Universidade do Porto. Faculdade de Ciência, Universidade do Minho. Centro de Matemática, Portugal. Ministério da Ciência e do Ensino Superior, Fundação para a Ciência e a Tecnologia (FCT), European Social Fund (ESF), Ministerio CTES

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