[1] C.-S. Hsieh, Y. Liang, A.J. Tyznik, S.G. Self, D. Liggitt, A.Y. Rudensky, Recognition of the peripheral self by naturally arising CD25+CD4+
T cell receptors, Immunity 21 (2004) 267–277.
[2] S. Sakaguchi, Naturally arising CD4+ regulatory T cells for immunological self-tolerance and negative control of immune responses, Annual
Review of Immunology 22 (2004) 531–562.
[3] A.M. Thornton, E.M. Shevach, CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting
interleukine 2 production, The Journal of Experimental Medicine 188 (2) (1998) 287–296.
[4] E.M. Shevach, R.S. McHugh, C.A. Piccirillo, A.M. Thornton, Control of T-cell activation by CD4(+)CD25(+) suppressor T cells,
Immunological Reviews 182 (2001) 58–67.
[5] G.C. Furtado, M.A. Curotto de Lafaille, N. Kutchukhidze, J.J. Lafaille, IInterleukin 2 signaling is required for CD4+ regulatory T cell
function, The Journal of Experimental Medicine 196 (6) (2002) 851–857.
[6] M. de la Rosa, S. Rutz, H. Dorninger, A. Scheffold, Interleukin-2 is essential for CD4+CD25+ regulatory T cells function, European Journal
of Immunology 34 (9) (2004) 2480–2488.
[7] A.M. Thornton, E.E. Donovan, C.A. Piccirillo, E.M. Shevach, Cutting edge: IL-2 is critically required for the in vitro activation of
CD4(+)CD25(+) T cell suppressor function, The Journal of Immunology 172 (2004) 6519–6523.
[8] A.M. Thornton, E.M. Shevach, Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific, The Journal
of Immunology 164 (2000) 183–190.
[9] C. Tanchot, F. Vasseur, C. Pontoux, C. Garcia, A. Sarukhan, Immune regulation by self-reactive T cells is antigen specific, The Journal of
Immunology 172 (2004) 4285–4291.
[10] N.J. Burroughs, B.M.P.M. Oliveira, A.A. Pinto, Regulatory T cell adjustment of quorum growth thresholds and the control of local immune
responses, Journal of Theoretical Biology 241 (2006) 134–141.
[11] K.S. Schluns, W.C. Kieper, S.C. Jameson, L. Lefrancois, Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo,
Nature Immunology 1 (2000) 426–432.
[12] S. Nagata, Fas ligand-induced apoptosis, Annual Review of Genetics 33 (1999) 29–55.
[13] C. Michie, A. McLean, C. Alcock, P. Beverley, Life-span of human lymphocyte subsets defined by CD45 isoforms, Nature 360 (1992)
264–265.
[14] D. Moskophidis, M. Battegay, M. van den Broek, E. Laine, U. Hoffmann-Rohrer, R. Zinkernagel, Role of virus and host variables in virus
persistence or immunopathological disease caused by a noncytolytic virus, The Journal of General Virology 76 (1995) 381.
[15] H. Veiga-Fernandes, U. Walter, C. Bourgeois, A. McLean, B. Rocha, Response of naive and memory CD8+ T cells to antigen stimulation in
vivo, Nature Immunology 1 (2000) 47–53.
[16] P.M. Anderson, M.A. Sorenson, Effects of route and formulation on clinical pharmacokinetics of interleukine-2, Clinical Pharmacokinetics
27 (1994) 19–31.
[17] J.W. Lowenthal, W.C. Greene, Contrasting interleukine 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human
high-affinity interleukine 2 receptor, The Journal of Experimental Medicine 166 (1987) 1156–1161.
[18] R.J. de Boer, P. Hogeweg, Immunological discrimination between self and non-self by precursor depletion and memory accumulation, Journal
of Theoretical Biology 124 (1987) 343.
[19] A.R. McLean, Modelling T cell memory, Journal of Theoretical Biology 170 (1994) 63–74.
[20] C. Utzny, N.J. Burroughs, Perturbation theory analysis of competition in a heterogeneous population, Physica D 175 (2003) 109–126.
[21] R.E. Callard, J. Stark, A.J. Yates, Fratricide: A mechanism for T memory-cell homeostasis, Trends in Immunology 24 (2003) 370–375.
[22] K. Leon, R. Perez, A. Lage, J. Carneiro, Modelling T-cell-mediated suppression dependent on interactions in multicellular conjugates, Journal
of Theoretical Biology 207 (2000) 231–254.
[23] K. Leon, A. Lage, J. Carneiro, Tolerance and immunity in a mathematical model of T-cell mediated suppression, Journal of Theoretical
Biology 225 (2003) 107–126.
[24] N.J. Burroughs, B.M.P.M. Oliveira, A.A. Pinto, H. Sequeira, Stability analysis of a model of local immune responses with regulatory T cells
(submitted for publication).
[25] M.J.B. van Stipdonk, E.E. Lemmens, S.P. Schoenberger, Naive ctls require a single brief period of antigenic stimulation for clonal expansion
and differentiation, Nature Immunology 2 (2001) 423–429.
[26] C. Chan, R.I. Lechler, A.J.T. George, Tolerance mechanisms and recent progress, Transplantation Proceedings 36 (2004) 561S–569S.