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Sensibility of the quorum growth thresholds controlling local immune responses
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Burroughs, Nigel John, Oliveira, B. M. P. M., Pinto, Alberto A. and Sequeira, H. J. T. (2008) Sensibility of the quorum growth thresholds controlling local immune responses. Mathematical and Computer Modelling, Vol.47 (No.7-8). pp. 714-725. doi:10.1016/j.mcm.2007.06.007
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Official URL: http://dx.doi.org/10.1016/j.mcm.2007.06.007
Abstract
The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs. (C) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QA Mathematics Q Science > QR Microbiology > QR180 Immunology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||
| Library of Congress Subject Headings (LCSH): | Immunology -- Mathematical models, T cells, Immune response -- Regulation, Cytokines -- Secretion | ||||
| Journal or Publication Title: | Mathematical and Computer Modelling | ||||
| Publisher: | Pergamon | ||||
| ISSN: | 0895-7177 | ||||
| Official Date: | April 2008 | ||||
| Dates: |
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| Volume: | Vol.47 | ||||
| Number: | No.7-8 | ||||
| Number of Pages: | 12 | ||||
| Page Range: | pp. 714-725 | ||||
| DOI: | 10.1016/j.mcm.2007.06.007 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Universidade do Porto. Faculdade de Ciência, Universidade do Minho. Centro de Matemática, Portugal. Ministério da Ciência e do Ensino Superior, Fundação para a Ciência e a Tecnologia (FCT), European Social Fund (ESF), Ministerio CTES |
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