Whitworth, David E. and Cock, Peter J. A.. (2008) Two-component systems of the myxobacteria : structure, diversity and evolutionary relationships. Microbiology, Vol.154 (No.2). pp. 360-372. ISSN 1350-0872

Full text not available from this repository.

Abstract

Two-component systems (TCSs) are a large family of signalling pathways characterized by the successive transfer of phosphoryl groups between the histidine and aspartate residues of paired histidine kinase and response regulator proteins. With the availability of genome sequences for four genera of myxobacteria it has become possible to assess the genomic complements of myxobacterial TCS genes and to characterize features of their organization and evolutionary heritage. In this study we have compiled lists of the TCS genes within myxobacterial genomes and characterized their domain architecture, gene organization and evolutionary relationships. In order to provide an appropriate context for our conclusions, where possible we have compared myxobacterial TCSs with those found in 316 other completely sequenced bacteria. Myxobacteria have the largest number of TCSs of any organisms. An unusually low proportion of TCS genes are paired in myxobacterial genomes, and myxobacterial histidine kinases also seem to sense internal signals to an unusual degree, Phylogenetic evidence has allowed us to suggest homologous relationships of proteins across the myxobacteria, and it appears that myxobacterial TCS evolution has been dominated by duplications, gene rearrangements and changes in sensory domain complements. The systematic classification of the TCS proteins of the myxobacteria presented here should also provide a framework for future experimental studies on two-component regulation in these organisms.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science > Molecular Organisation and Assembly in Cells (MOAC)
Library of Congress Subject Headings (LCSH):	Myxobacterales, Cellular signal transduction, Protein kinases
Journal or Publication Title:	Microbiology
Publisher:	Society for General Microbiology
ISSN:	1350-0872
Date:	February 2008
Volume:	Vol.154
Number:	No.2
Number of Pages:	13
Page Range:	pp. 360-372
Identification Number:	10.1099/mic.0.2007/013672-0
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number:	BBD0039891 (BBSRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/30408

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item