Abou Neel, Ensanya A., O'Dell, Luke A., Smith, Mark E. and Knowles, Jonathan C.. (2008) Processing, characterisation, and biocompatibility of zinc modified metaphosphate based glasses for biomedical applications. Journal of Materials Science: Materials in Medicine, Vol.19 (No.4). pp. 1669-1679. ISSN 0957-4530

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Abstract

Bulk and structural properties of zinc oxide (0 up to 20 mol%) containing phosphate glasses, developed for biomedical applications, were investigated throughout this study using differential thermal analysis (DTA), differential scanning calorimetry, X-ray powder diffraction and P-31 and Na-23 MAS NMR. Surface wettability and MG63 viability were also considered for surface characterisation of these glasses. The results indicated that incorporation of zinc oxide as a dopant into phosphate glasses produced a significant increase in density; however, the thermal properties presented in glass transition, and melting temperatures were reduced. NaZn(PO3)(3) was detected in the X-Ray Powder Diffraction Analysis (XRD) trace of zinc containing glasses, and the proportion of this phase increased with increasing zinc oxide content. NaCa(PO3)(3) as a second main phase and CaP2O6 in minor amounts were also detected. The P-31 and Na-23 MAS NMR results suggested that the relative abundances of the Q(1) and Q(2) phosphorus sites, and the local sodium environment were unaffected as CaO was replaced by ZnO in this system. The replacement of CaO with ZnO did seem to have the effect of increasing the local disorder of the Q(2) metaphosphate chains, but less so for the Q(1) chain-terminating sites which were already relatively disordered due to the proximity of modifying cations. Glasses with zinc oxide less than 5 mol% showed higher surface wettability, while those with 5 up to 20 mol% showed comparable wettability as zinc oxide free glasses. Regardless of the high hydrophilicity and surface reactivity of these zinc oxide containing glasses, they had lower biocompatibility, in particular 10-20 mol% ZnO, compared to both zinc free glasses and Thermanox (R). This may be associated with the release of significant amount of Zn2+ enough to be toxic to MG63.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General) T Technology > TP Chemical technology
Divisions:	Administration > Vice Chancellor's Office Faculty of Science > Physics
Library of Congress Subject Headings (LCSH):	Glass in medicine, Biomedical engineering, Biomedical materials, Soluble glass, Ceramics in medicine
Journal or Publication Title:	Journal of Materials Science: Materials in Medicine
Publisher:	Springer New York LLC
ISSN:	0957-4530
Date:	April 2008
Volume:	Vol.19
Number:	No.4
Number of Pages:	11
Page Range:	pp. 1669-1679
Identification Number:	10.1007/s10856-007-3313-1
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC)
Version or Related Resource:	Paper presented at: 21st European Conference on Biomaterials, Brighton, England, Sep 09-13, 2007
Type of Event:	Conference
References:	1. L. L. HENCH and J. M. POLAK, Science 295(5557) (2002) 1014 2. J. C. KNOWLES, J. Mater. Chem. 13 (2003) 2395 3. K. FRANKS, I. ABRAHAMS and J. C. KNOWLES, J. Mater. Sci. Mater. Med. 11 (2000) 609 4. V. SALIH, K. FRANKS, M. JAMES, G. W. HASTINGS, and J. C. KNOWLES, J. Mater. Sci. Mater. Med. 11 (2000) 615 5. X. YU, D. E. DAY, G. J. LONG and R. K. BROW, J. Non-Cryst. Solids 215 (1997) 21 6. C. S. RAY, X. FANG, M. KARABULUT, G. K. MARASINGHE and D. E. DAY, J. Non-Cryst. Solids 249(1) (1999) 1 7. I. AHMED, C. A. COLLINS, M. P. LEWIS, I. OLSEN and J. C. KNOWLES, Biomaterials 25 (2004) 3223 8. E. A. ABOU NEEL, I. AHMED, J. J. BLAKER, A. BISMARCK, A. R. BOCCACCINI, M. P. LEWIS, S. N. NAZHAT and J. C. KNOWLES, Acta Biomaterialia 1 (2005) 553 9. E. A. ABOU NEEL, I. AHMED, J. PRATTEN, S. N. NAZHAT and J. C. KNOWLES, Biomaterials 26 (2005) 2247 10. R. SHAH, A. C. M. SINANAN, J. C. KNOWLES, N. P. HUNT and M. P. LEWIS, Biomaterials 26 (2005) 1497 11. M. NAVARRO, M.-P. GINEBRA and J. A. PLANELL, J. Biomed. Mater. Res. 67A (2003) 1009 12. V. RAJENDRAN, A. V. GAYATHRI DEVI, M. AZOOZ and F. H. EL-BATAL, J. Non-Cryst. Solids 353(1) (2006) 77 13. E. A. ABOU NEEL, T. MIZOGUCHI, M. ITO, M. BITAR, V. SALIH and J. C. KNOWLES, Biomaterials 28 (2007) 2967 14. E. A. ABOU NEEL and J. C. KNOWLES, J Mater. Sci. Mater. Med. doi: 10.1007/s10856-007-3079-5 15. V. SALIH, A. PATEL and J. C. KNOWLES, Biomed. Mater. 2 (2007) 1 16. K. FRANKS, ‘The structure and properties of soluble phosphate based glasses, PhD thesis, University of London (2000) 17. M. KAMITAKAHARA, C. OHTUSUKI, H. INADA, M. TANIHARA, and T. MIYAZAKI, Acta Biomaterialia 2 (2006) 467 18. R. M. DAY and A. R. BOCCACCINI, J. Biomed. Mater. Res. 73A (2005) 73 19. P. PETRINI, C. R. ARCIOLA, I. PEZAALI, S. BOZZINI, L. MONTANARO, M. C. TANZI, P. SPEZIALI and L. VISAI, Int. J. Artif. Organs 29(4) (2006) 434 20. D. MASSIOT, F. FAYON, M. CAPRON, I. KING, S. LE CALVE´ , B. ALONSO, J.-O. DURAND, B. BUJOLI, Z. GAN and G. HOATSON, Magn. Reson. Chem. 40 (2002) 70 21. T. F. KEMP, High Field Solid State 27Al NMR of ceramics and glasses. Masters Thesis, University of Warwick (2004) 22. D. R. LIDE, ‘‘Handbook of Chemistry and Physics’’, 74th edn. (The Chemical Rubber Publishing Company, 1993–1994), pp. 4–126 & 12–160 23. P. Y. SHIH, S. W. YUNG and T. S. CHIN, J. Non-Cryst. Solids 224 (1998) 143 24. L. A. O’DELL, S. L. P. SAVIN, A. V. CHADWICK and M. E. SMITH, Appl. Magn. Reson. 32 (2007) 527 25. R. K. BROW, R. J. KIRKPATRICK and G. L. TURNER, J. Non- Cryst. Solids 116 (1990) 39 26. R. K. BROW, C. C. PHIFER, G. L. TURNER and R. J. KIRKPATRICK, J. Am. Ceram. Soc. 74 (1991) 1287 27. J. J. BLAKER, V. MAQUET, A. R. BOCCACCINI, R. JE´ROˆ ME and A. BISMARCK, e-polymers (2005) Art No. 23 Apr 1 28. S. WU, ‘‘Polymer Interface and Adhesion’’ (Marcel Dekker, 1982) 29. R. J. GOOD and C. J. Van OSS, in ‘‘The Modern Theory of Contact Angles and the Hydrogen Bond Components of Surface Energies: In Modern Approaches to Wettability edited by M. E. Schrader and G. I. Loeb (Plenum, New York, 1992) 30. F. M. FOWKES, Ind. Eng. Chem. 56(12) (1964) 40 31. F. M. FOWKES, J. Phys. Chem. 66(2) (1962) 382 32. D. K. OWENS and R. C. WENDT, J. Appl. Polym. Sci. 13 (1969) 1741 33. A. ITO, K. OJIMA, H. NAITO, N. ICHINOSE and T. TATEISHI, J. Biomed. Mater. Res. 50 (2000) 178 34. W. AINA, A. PERARDI, L. BERGANDI, G. MALAVASI, L. MENABUE, C. MORTERRA and D. GHIGO, Chem. Biol. Interact. 167 (2007) 207 35. Y. SOGO, T. SAKURAI, K. ONUMA and A. ITO, J. Biomed. Mater. Res. 62 (2002) 457
URI:	http://wrap.warwick.ac.uk/id/eprint/30414

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