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Noninvasive prenatal diagnosis of aneuploidy using cell-free nucleic acids in maternal blood : promises and unanswered questions
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Puszyk, William Matthew, Crea, F. (Francesco) and Old, R. W. (2008) Noninvasive prenatal diagnosis of aneuploidy using cell-free nucleic acids in maternal blood : promises and unanswered questions. Prenatal Diagnosis, Vol.28 (No.1). pp. 1-6. doi:10.1002/pd.1902
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Official URL: http://dx.doi.org/10.1002/pd.1902
Abstract
The discovery of cell-free fetal (cff) DNA and RNA in the maternal circulation has driven developments in noninvasive prenatal diagnosis (NIPD) for the past decade. Detection of paternally derived alleles in cff DNA is becoming well established. Now much interest is focussing on NIPD of fetal chromosomal abnormalities, such as trisomy 2 1, which is a considerable challenge because this demands accurate quantitative measurements of the amounts of specific cff DNA or cff RNA sequences in maternal blood samples. Emerging strategies for distinguishing and quantifying the fetal nucleic acids in the maternal circulation promise continued development of the field, and pose a number of unanswered questions. Copyright (c) 2007 John Wiley & Sons, Ltd.
| Item Type: | Journal Item | ||||
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| Subjects: | R Medicine > RB Pathology R Medicine > RG Gynecology and obstetrics |
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| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
| Library of Congress Subject Headings (LCSH): | Diagnosis, Noninvasive -- Evaluation, Prenatal diagnosis -- Evaluation, Aneuploidy, Trisomy, Down syndrome, Human chromosome abnormalities, Nucleic acids | ||||
| Journal or Publication Title: | Prenatal Diagnosis | ||||
| Publisher: | John Wiley & Sons Ltd. | ||||
| ISSN: | 0197-3851 | ||||
| Official Date: | January 2008 | ||||
| Dates: |
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| Volume: | Vol.28 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 1-6 | ||||
| DOI: | 10.1002/pd.1902 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Funder: | European Commission (EC) | ||||
| Grant number: | LSHB-CT-2004-503243 (EC) |
Data sourced from Thomson Reuters' Web of Knowledge
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