An in-host model of acute infection : measles as a case study
Heffernan, J. M. and Keeling, Matthew James. (2008) An in-host model of acute infection : measles as a case study. Theoretical Population Biology , Vol.73 (No.1). pp. 134-147. ISSN 0040-5809Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.tpb.2007.10.003
The epidemiology of acute infections is strongly influenced by the immune status of individuals. In-host models can provide quantitative predictions of immune status and can thus offer valuable insights into the factors that influence transmission between individuals and the effectiveness of vaccination protocols with respect to individual immunity. Here we develop an in-host model of measles infection. The model explicitly considers the effects of immune system memory and C138 T-cells, which are key to measles clearance. The model is used to determine the effects of waning immunity through vaccination and infection, the effects of booster exposures or vaccines on the level of immunity, and the immune system characteristics that result in measles transmission (R-0 > 1) even if an individual has no apparent clinical symptoms. We find that the level of immune system CD8 T-cells at the time of exposure to measles determines whether an individual will experience a measles infection or simply a boost in immunity. We also find that the infected cell dynamics are a good indicator of measles transmission and the degree of symptoms that will be experienced. Our results indicate that the degree of immunity in adults is independent of the source of exposure in early childhood, be it vaccine or natural infection. Crown Copyright (C) 2007 Published by Elsevier Inc. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology
R Medicine > RC Internal medicine
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Faculty of Science > Mathematics
|Library of Congress Subject Headings (LCSH):||Infection -- Epidemiology, Measles, Immunology, Immune system, Virus diseases -- Mathematical models, Immune response -- Mathematical models|
|Journal or Publication Title:||Theoretical Population Biology|
|Number of Pages:||14|
|Page Range:||pp. 134-147|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Natural Sciences and Engineering Research Council Canada (NSERC), National Institutes of Health (U.S.) (NIH), Leverhulme Trust (LT)|
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