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The biosynthesis of peptidoglycan lipid-linked intermediates
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Bouhss, Ahmed, Trunkfield, Amy E., Bugg, Tim and Mengin-Lecreulx, Dominique (2008) The biosynthesis of peptidoglycan lipid-linked intermediates. FEMS Microbiology Reviews, Vol.32 (No.2). pp. 208-233. doi:10.1111/j.1574-6976.2007.00089.x
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Official URL: http://dx.doi.org/10.1111/j.1574-6976.2007.00089.x
Abstract
The biosynthesis of bacterial cell wall peptidoglycan is a complex process involving many different steps taking place in the cytoplasm (synthesis of the nucleotide precursors) and on the inner and outer sides of the cytoplasmic membrane (assembly and polymerization of the disaccharide-peptide monomer unit, respectively). This review summarizes the current knowledge on the membrane steps leading to the formation of the lipid II intermediate, i.e. the substrate of the polymerization reactions. It makes the point on past and recent data that have significantly contributed to the understanding of the biosynthesis of undecaprenyl phosphate, the carrier lipid required for the anchoring of the peptidoglycan hydrophilic units in the membrane, and to the characterization of the MraY and MurG enzymes which catalyze the successive transfers of the N-acetylmuramoyl-peptide and N-acetylglucosamine moieties onto the carrier lipid, respectively. Enzyme inhibitors and antibacterial compounds interfering with these essential metabolic steps and interesting targets are presented.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Peptidoglycans -- Synthesis | ||||
| Journal or Publication Title: | FEMS Microbiology Reviews | ||||
| Publisher: | Blackwell Publishing | ||||
| ISSN: | 0168-6445 | ||||
| Official Date: | March 2008 | ||||
| Dates: |
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| Volume: | Vol.32 | ||||
| Number: | No.2 | ||||
| Number of Pages: | 26 | ||||
| Page Range: | pp. 208-233 | ||||
| DOI: | 10.1111/j.1574-6976.2007.00089.x | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Description: | Review article |
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| Funder: | Centre national de la recherche scientifique (France) (CNRS), Sixth Framework Programme (European Commission) (FP6) | ||||
| Grant number: | LSHMCT-2003-503335 (FP6), LSHM-CT-2004-512138 (FP6) |
Data sourced from Thomson Reuters' Web of Knowledge
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