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Smith, F. Gao (Fang Gao), Linhartova, L., Johnston, A. Mcd. and Thickett, David R. (2008) Statins and sepsis. British Journal of Anaesthesia, Volume 100 (Number 3). pp. 288-298. doi:10.1093/bja/aem406
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Official URL: http://dx.doi.org/10.1093/bja/aem406
Abstract
Severe sepsis and septic shock is common and frequently fatal. Over the last few years, the primary treatments demonstrated to improve outcome from several major clinical trials have finally emerged. However, translating these recent therapeutic advances to routine clinical practice has proven controversial, and new approaches of additional strategies are continued to be developed. Given their pleiotropic effects related to many pathophysiological determinants of sepsis, statin therapy could be the next step in the search for adjuvant therapy. A future challenge may be to test both the efficacy and the safety by large randomized controlled clinical trials ascertaining the effects of statins administered at the onset of sepsis and in patients with severe sepsis or septic shock admitted into intensive care units.
Item Type: | Journal Item | ||||
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Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Septicemia -- Complications, Septic shock -- Complications, Immune response, Statins (Cardiovascular agents) | ||||
Journal or Publication Title: | British Journal of Anaesthesia | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 0007-0912 | ||||
Official Date: | March 2008 | ||||
Dates: |
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Volume: | Volume 100 | ||||
Number: | Number 3 | ||||
Number of Pages: | 11 | ||||
Page Range: | pp. 288-298 | ||||
DOI: | 10.1093/bja/aem406 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Pfizer Ltd. |
Data sourced from Thomson Reuters' Web of Knowledge
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