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A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan

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Chappell, M. J. (Michael J.), Evans, N. D., Errington, Rachel J., Khan, I. A., Campbell, L., Ali, Reza, Godfrey, Keith and Smith, Paul J. (Paul James), 1953-. (2008) A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan. Computer Methods and Programs in Biomedicine, Vol.89 (No.2). pp. 169-178. ISSN 0169-2607

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Official URL: http://dx.doi.org/10.1016/j.cmpb.2007.11.002

Abstract

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology T Technology > TA Engineering (General). Civil engineering (General)
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Pharmacokinetics -- Mathematical models, Cell cycle -- Mathematical models, Cancer cells, Cancer -- Treatment
Journal or Publication Title:	Computer Methods and Programs in Biomedicine
Publisher:	Elsevier Ireland Ltd.
ISSN:	0169-2607
Date:	February 2008
Volume:	Vol.89
Number:	No.2
Number of Pages:	10
Page Range:	pp. 169-178
Identification Number:	10.1016/j.cmpb.2007.11.002
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number:	88/E19305 (BBSRC)
Title of Event:	Workshop on Nordic Models of Capitalism
Location of Event:	Univ Birmingham, Birmingham, ENGLAND
Date(s) of Event:	OCT 08-09, 2004
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URI:	http://wrap.warwick.ac.uk/id/eprint/30637