Shih, Chi-Tin, Roche, Stephan and Roemer, Rudolf A.. (2008) Point-mutation effects on charge-transport properties of the tumor-suppressor gene p53. Physical Review Letters, Vol.100 (No.1). article no. 018105 . ISSN 0031-9007

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Abstract

We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective tight-binding models which simulate hole propagation along the DNA, a statistical analysis of mutation-induced charge transfer modifications is performed. In contrast to noncancerous mutations, mutation hot spots tend to result in significantly weaker changes of transmission properties. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Faculty of Science > Physics Faculty of Science > Centre for Scientific Computing
Library of Congress Subject Headings (LCSH):	Charge transfer, p53 antioncogene
Journal or Publication Title:	Physical Review Letters
Publisher:	American Physical Society
ISSN:	0031-9007
Date:	11 January 2008
Volume:	Vol.100
Number:	No.1
Number of Pages:	4
Page Range:	article no. 018105
Identification Number:	10.1103/PhysRevLett.100.018105
Status:	Peer Reviewed
Publication Status:	Published
Funder:	National Science Council of Taiwan (NSCTW), National Center for Theoretical Sciences (Taiwan) (NCTS), Leverhulme Trust (LT)
Grant number:	95-2112-M-029-003 (NSCTW), F/00215/AH (LT)
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URI:	http://wrap.warwick.ac.uk/id/eprint/30701

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