Point-mutation effects on charge-transport properties of the tumor-suppressor gene p53
Shih, Chi-Tin, Roche, Stephan and Roemer, Rudolf A.. (2008) Point-mutation effects on charge-transport properties of the tumor-suppressor gene p53. Physical Review Letters, Vol.100 (No.1). article no. 018105 . ISSN 0031-9007Full text not available from this repository.
Official URL: http://dx.doi.org/10.1103/PhysRevLett.100.018105
We report on a theoretical study of point mutations effects on charge transfer properties in the DNA sequence of the tumor-suppressor p53 gene. On the basis of effective tight-binding models which simulate hole propagation along the DNA, a statistical analysis of mutation-induced charge transfer modifications is performed. In contrast to noncancerous mutations, mutation hot spots tend to result in significantly weaker changes of transmission properties. This suggests that charge transport could play a significant role for DNA-repairing deficiency yielding carcinogenesis.
|Item Type:||Journal Article|
|Subjects:||Q Science > QC Physics
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
|Divisions:||Faculty of Science > Physics
Faculty of Science > Centre for Scientific Computing
|Library of Congress Subject Headings (LCSH):||Charge transfer, p53 antioncogene|
|Journal or Publication Title:||Physical Review Letters|
|Publisher:||American Physical Society|
|Official Date:||11 January 2008|
|Number of Pages:||4|
|Page Range:||article no. 018105|
|Funder:||National Science Council of Taiwan (NSCTW), National Center for Theoretical Sciences (Taiwan) (NCTS), Leverhulme Trust (LT)|
|Grant number:||95-2112-M-029-003 (NSCTW), F/00215/AH (LT)|
 R. G. Endres, D. L. Cox, and R. P. Singh, Rev. Mod. Phys.
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