Quantification of lung injury using ventilation and perfusion distributions obtained from gamma scintigraphy
Brook, B. S., Murphy, C. M., Breen, D., Miles, A. W., Tilley, D. G. and Wilson, A. J.. (2007) Quantification of lung injury using ventilation and perfusion distributions obtained from gamma scintigraphy. Physiological Measurement, Vol.28 (No.12). pp. 1451-1464. ISSN 0967-3334Full text not available from this repository.
Official URL: http://dx.doi.org/10.1088/0967-3334/28/12/001
This paper explores the potential of isotope V/Q lung scans to quantify lung disease. Areas of restricted perfusion in subjects with a pulmonary embolus (PE) were identified in 3D reconstructions of V/Q images achieved using anatomical data from the Visible Human Project. From these, the extent of lung damage was quantified. Significant differences in the values of both LogSD V and LogSDQ (p > 0.05) obtained from plots of V and Q against Log(V/Q) were found between normal subjects and subjects with a PE, but no correlation was found between either of these parameters and the degree of lung damage in subjects with a PE (p > 0.05). Whilst V/Q values were lognormally distributed, the V/Q distributions from the subjects with a PE failed to show the bimodal distribution predicted from theoretical considerations and MIGET measurements previously reported. There was a statistically significant difference in the mean and standard deviation values of the V/Q distributions between normal subject and subjects with a PE (p < 0.05) but not in the median values (p > 0.05). There was no correlation between the mean, median and standard deviation of the distributions from the subjects with a PE and the percentage of damage present (p > 0.05).
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
|Divisions:||Faculty of Science > Physics|
|Journal or Publication Title:||Physiological Measurement|
|Publisher:||Institute of Physics Publishing Ltd.|
|Number of Pages:||14|
|Page Range:||pp. 1451-1464|
|Access rights to Published version:||Restricted or Subscription Access|
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