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Quantification of lung injury using ventilation and perfusion distributions obtained from gamma scintigraphy
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Brook, B. S., Murphy, C. M., Breen, D., Miles, A. W., Tilley, D. G. and Wilson, A. J. (2007) Quantification of lung injury using ventilation and perfusion distributions obtained from gamma scintigraphy. Physiological Measurement, Vol.28 (No.12). pp. 1451-1464. doi:10.1088/0967-3334/28/12/001
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Official URL: http://dx.doi.org/10.1088/0967-3334/28/12/001
Abstract
This paper explores the potential of isotope V/Q lung scans to quantify lung disease. Areas of restricted perfusion in subjects with a pulmonary embolus (PE) were identified in 3D reconstructions of V/Q images achieved using anatomical data from the Visible Human Project. From these, the extent of lung damage was quantified. Significant differences in the values of both LogSD V and LogSDQ (p > 0.05) obtained from plots of V and Q against Log(V/Q) were found between normal subjects and subjects with a PE, but no correlation was found between either of these parameters and the degree of lung damage in subjects with a PE (p > 0.05). Whilst V/Q values were lognormally distributed, the V/Q distributions from the subjects with a PE failed to show the bimodal distribution predicted from theoretical considerations and MIGET measurements previously reported. There was a statistically significant difference in the mean and standard deviation values of the V/Q distributions between normal subject and subjects with a PE (p < 0.05) but not in the median values (p > 0.05). There was no correlation between the mean, median and standard deviation of the distributions from the subjects with a PE and the percentage of damage present (p > 0.05).
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Physics | ||||
| Journal or Publication Title: | Physiological Measurement | ||||
| Publisher: | Institute of Physics Publishing Ltd. | ||||
| ISSN: | 0967-3334 | ||||
| Official Date: | December 2007 | ||||
| Dates: |
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| Volume: | Vol.28 | ||||
| Number: | No.12 | ||||
| Number of Pages: | 14 | ||||
| Page Range: | pp. 1451-1464 | ||||
| DOI: | 10.1088/0967-3334/28/12/001 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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