Billyard, Tom, McTernan, P. G. (Philip G.) and Kumar, Sudhesh (2007) Potential therapies based on antidiabetic peptides. Best Practice & Research Clinical Endocrinology & Metabolism, Vol.21 (No.4). pp. 641-655. ISSN 1521-690X

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Abstract

Since adipose tissue was shown to be more than a storage organ, the many cytokines it produces have been identified, along with their roles in energy homeostasis, appetite, and insulin resistance. Concurrently, numerous gut hormones with a diversity of effects have been discovered. They include, amongst many others, peptide YY, ghrelin and oxyntomodulin. As these peptides have been investigated, the potential for their use as novel anti-obesity and antidiabetic therapies has been realized. In this chapter we describe the actions of four of the peptides that have been proposed as the basis for promising new therapies for diabetes: leptin, adiponectin, obestatin and peptide YY They each have an effect on appetite and, directly or indirectly, on glucose metabolism. We synthesize available data for these peptides and consider the therapeutic potential of each.

Item Type:	Journal Item
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Best Practice & Research Clinical Endocrinology & Metabolism
Publisher:	Bailliere Tindall
ISSN:	1521-690X
Date:	December 2007
Volume:	Vol.21
Number:	No.4
Number of Pages:	15
Page Range:	pp. 641-655
Identification Number:	10.1016/i.beem.2007.07.006
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Related URLs:	Publisher
URI:	http://wrap.warwick.ac.uk/id/eprint/30772

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