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Potential therapies based on antidiabetic peptides

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Billyard, Tom, McTernan, P. G. (Philip G.) and Kumar, Sudhesh (2007) Potential therapies based on antidiabetic peptides. Best Practice & Research Clinical Endocrinology & Metabolism, Vol.21 (No.4). pp. 641-655. ISSN 1521-690X

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Official URL: http://dx.doi.org/10.1016/i.beem.2007.07.006

Abstract

Since adipose tissue was shown to be more than a storage organ, the many cytokines it produces have been identified, along with their roles in energy homeostasis, appetite, and insulin resistance. Concurrently, numerous gut hormones with a diversity of effects have been discovered. They include, amongst many others, peptide YY, ghrelin and oxyntomodulin. As these peptides have been investigated, the potential for their use as novel anti-obesity and antidiabetic therapies has been realized. In this chapter we describe the actions of four of the peptides that have been proposed as the basis for promising new therapies for diabetes: leptin, adiponectin, obestatin and peptide YY They each have an effect on appetite and, directly or indirectly, on glucose metabolism. We synthesize available data for these peptides and consider the therapeutic potential of each.

Item Type:

Journal Item

Subjects:

R Medicine > RC Internal medicine

Divisions:

Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Medicine > Warwick Medical School

Journal or Publication Title:

Best Practice & Research Clinical Endocrinology & Metabolism

Publisher:

Bailliere Tindall

ISSN:

1521-690X