Block, M., Schoell, E. and Drasdo, D. (2007) Classifying the expansion kinetics and critical surface dynamics of growing cell populations. Physical Review Letters, Vol.99 (No.24). doi:10.1103/PhysRevLett.99.248101 ISSN 0031-9007.

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Abstract

We systematically study the growth kinetics and the critical surface dynamics of cell monolayers by a class of computationally efficient cellular automaton models avoiding lattice artifacts. Our numerically derived front velocity relationship indicates the limitations of the Fisher-Kolmogorov-Petrovskii-Piskounov equation for tumor growth simulations. The critical surface dynamics corresponds to the Kardar-Parisi-Zhang universality class, which disagrees with the interpretation by Bru et al. of their experimental observations as generic molecular-beam-epitaxy-like growth, questioning their conjecture that a successful therapy should lead away from molecular beam epitaxy.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics
Divisions:	Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Journal or Publication Title:	Physical Review Letters
Publisher:	American Physical Society
ISSN:	0031-9007
Official Date:	14 December 2007
Dates:	Date Event 14 December 2007 Published
Volume:	Vol.99
Number:	No.24
Number of Pages:	4
DOI:	10.1103/PhysRevLett.99.248101
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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