The Library
Colonic fermentation – more than meets the nose
Tools
Tools
Tools
Arasaradnam, Ramesh P., Pharaoh, Mark W., Williams, Geraint J., Nwokolo, Chuka U., Bardhan, Karna Dev and Kumar, Sudhesh (2009) Colonic fermentation – more than meets the nose. Medical Hypotheses, Vol.73 (No.5). pp. 753-756. doi:10.1016/j.mehy.2009.04.027
![[img]](http://wrap.warwick.ac.uk/style/images/fileicons/application_pdf.png) |
PDF
WRAP_Arasadnam_Medical_Hypothesis_Arasaradnam.pdf - Draft Version - Requires a PDF viewer. Download (229Kb) |
Official URL: http://dx.doi.org/10.1016/j.mehy.2009.04.027
Abstract
Fermentation of undigested foods in the colon by its resident bacteria affects not only colonic health (protection against inflammation and tumour formation) but also influences metabolic health. Studying fermentation directly is difficult for lack of access. We hypothesise that the anatomical structure of the colon is suited to act as a fermenting chamber with the gaseous molecules (VOCs) emitted having direct effects on the colonocytes as well as gut neural and metabolic effects. We refer to this complex system as the ‘fermentome’, and further hypothesise that alteration in the ‘fermentome’ through dietary modification will have a direct impact on colonic as well as metabolic health and disease. The VOCs emitted may play a role in bacterial chemical signalling within the colon but importantly could also function as a ‘gas’ biomarker. Measurement of such VOCs through non-invasive methods would have important application as a hypothesis-generating tool with subsequent clinical application.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
||||
| Divisions: | Faculty of Science > WMG (Formerly the Warwick Manufacturing Group) Faculty of Medicine > Warwick Medical School |
||||
| Library of Congress Subject Headings (LCSH): | Fermentation -- Research, Enterobacteriaceae -- Research, Volatile organic compounds -- Research, Biological control systems | ||||
| Journal or Publication Title: | Medical Hypotheses | ||||
| Publisher: | Churchill Livingstone | ||||
| ISSN: | 0306-9877 | ||||
| Official Date: | November 2009 | ||||
| Dates: |
|
||||
| Volume: | Vol.73 | ||||
| Number: | No.5 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 753-756 | ||||
| DOI: | 10.1016/j.mehy.2009.04.027 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
