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The design of organometallic ruthenium arene anticancer agents
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Dougan, Sarah J. and Sadler, P. J. (2007) The design of organometallic ruthenium arene anticancer agents. Chimia, Volume 61 (Number 11). pp. 704-715. doi:10.2533/chimia.2007.704 ISSN 0009-4293.
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Official URL: http://dx.doi.org/10.2533/chimia.2007.704
Abstract
Organometallic half-sandwich Ru-II anticancer complexes of the type [(eta(6)-arene)Ru(yZ)X](n) can exhibit interesting anticancer activity. We review the comparative aqueous solution chemistry (hydrolysis rates, pKa values of aqua complexes), cancer cell cytotoxicities, cross-resistance, reactivity towards nucleobases, DNA and important biomolecules for complexes containing various arenes, N,N- or N,O- or O,O-chelating ligands as YZ, and monodentate leaving groups X. We show that the choice of these ligands can have a dramatic effect on reactivity. The same is true for analogous Os-II arene complexes. The interpretation of structure-activity relationships requires an understanding of reactions of these organometallic complexes under biological test conditions.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Chimia | ||||
Publisher: | Schweizerische Chemische Gesellschaft | ||||
ISSN: | 0009-4293 | ||||
Official Date: | 2007 | ||||
Dates: |
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Volume: | Volume 61 | ||||
Number: | Number 11 | ||||
Number of Pages: | 12 | ||||
Page Range: | pp. 704-715 | ||||
DOI: | 10.2533/chimia.2007.704 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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