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Establishing the stochastic nature of intracellular calcium oscillations from experimental data
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Perc, Matjaz, Green, Anne K., Dixon, C. Jane and Marhl, Marko. (2008) Establishing the stochastic nature of intracellular calcium oscillations from experimental data. Biophysical Chemistry, Vol.132 (No.1). pp. 33-38. ISSN 0301-4622
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Official URL: http://dx.doi.org/10.1016/j.bpc.2007.10.002
Abstract
Calcium has been established as a key messenger in both intra- and intercellular signaling. Experimentally observed intracellular calcium responses to different agonists show a variety of behaviors from simple spiking to complex oscillatory regimes. Here we study typical experimental traces of calcium oscillations in hepatocytes obtained in response to phenylephrine and ATP. The traces were analyzed with methods of nonlinear time series analysis in order to determine the stochastic/deterministic nature of the intracellular calcium oscillations. Despite the fact that the oscillations appear, visually, to be deterministic yet perturbed by noise, our analyses provide strong evidence that the measured calcium traces in hepatocytes are prevalently of stochastic nature. In particular, bursting calcium oscillations are temporally correlated Gaussian series distorted by a monotonic, instantaneous, time-independent function, whilst the spiking behavior appears to have a dynamical nonlinear component whereby the overall determinism level is still low. The biological importance of this finding is discussed in relation to the mechanisms incorporated in mathematical models as well as the role of stochasticity and determinism at cellular and tissue levels which resemble typical statistical and thermodynamic effects in physics. (C) 2007 Elsevier B.V. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine > Warwick Medical School > Education Development and Research Faculty of Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Time-series analysis, Intracellular calcium, Oscillating chemical reactions, Stochastic analysis |
| Journal or Publication Title: | Biophysical Chemistry |
| Publisher: | Elsevier Science Inc |
| ISSN: | 0301-4622 |
| Date: | January 2008 |
| Volume: | Vol.132 |
| Number: | No.1 |
| Number of Pages: | 6 |
| Page Range: | pp. 33-38 |
| Identification Number: | 10.1016/j.bpc.2007.10.002 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | British Council (BC), Slovenian Research Agency (ARRS), Wellcome Trust (London, England) |
| Grant number: | BI-GB/06-013 (BC), 065845 (WT), 059089 (WT), Z1-9629 (ARRS) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/30905 |
Data sourced from Thomson Reuters' Web of Knowledge
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