Towards a low-cost optical iriosensor system for biomedical immunoassay applications
Gardner, J. W. (Julian W.), 1958-, Apostolidou, A., Cole, M., Dowson, Christopher G., Edmunds, S. and Sehra, G. (2007) Towards a low-cost optical iriosensor system for biomedical immunoassay applications. In: 5th IASTED International Conference on Biomedical Engineering, Innsbruck, AUSTRIA, FEB 14-16, 2007. Published in: Proceedings of the Fifth IASTED International Conference on Biomedical Engineering pp. 277-282.Full text not available from this repository.
A novel, low-cost optical measurement system has been designed for biomedical applications such as immunoassays. The system comprises a rapid-prototyped ABS plastic housing, 500 nm LED source, 530 nm UV filter, and 540 nm silicon photodiode receiver with a custom-built high gain precision amplifier. The sensor system has been designed to measure the fluorescence of different bioliquids in a standard glass test-tube. In addition, a small disc magnet can be inserted to enhanced signal-to-noise in liquids containing fluorophore-labelled magnetic beads. Our preliminary results show that the baseline optical signal depends weakly on the refractive index of the liquid and more strongly on its opaqueness. Removing this baseline signal permits the measurement of FTIC solutions down to concentrations of about 100 nMol. In addition, the insertion of the magnet was found to enhance significantly the optical signal in translucent liquids with low bead concentrations but, interesting, not in opaque ones. We believe that this low-cost (less than EURO150) optical immunoassay sensor has potential applications such as detecting progesterone and bacteria levels in milk, water, saliva, urine, and blood.
|Item Type:||Conference Item (UNSPECIFIED)|
|Subjects:||Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software
T Technology > TL Motor vehicles. Aeronautics. Astronautics
|Journal or Publication Title:||Proceedings of the Fifth IASTED International Conference on Biomedical Engineering|
|Publisher:||ACTA PRESS ANAHEIM|
|Number of Pages:||6|
|Page Range:||pp. 277-282|
|Title of Event:||5th IASTED International Conference on Biomedical Engineering|
|Location of Event:||Innsbruck, AUSTRIA|
|Date(s) of Event:||FEB 14-16, 2007|
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