Gardner, J. W., Apostolidou, A., Cole, M., Dowson, Christopher G., Edmunds, S. and Sehra, G. (2007) Towards a low-cost optical iriosensor system for biomedical immunoassay applications. In: 5th IASTED International Conference on Biomedical Engineering, Innsbruck, AUSTRIA, FEB 14-16, 2007. Published in: Proceedings of the Fifth IASTED International Conference on Biomedical Engineering pp. 277-282.

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Abstract

A novel, low-cost optical measurement system has been designed for biomedical applications such as immunoassays. The system comprises a rapid-prototyped ABS plastic housing, 500 nm LED source, 530 nm UV filter, and 540 nm silicon photodiode receiver with a custom-built high gain precision amplifier. The sensor system has been designed to measure the fluorescence of different bioliquids in a standard glass test-tube. In addition, a small disc magnet can be inserted to enhanced signal-to-noise in liquids containing fluorophore-labelled magnetic beads. Our preliminary results show that the baseline optical signal depends weakly on the refractive index of the liquid and more strongly on its opaqueness. Removing this baseline signal permits the measurement of FTIC solutions down to concentrations of about 100 nMol. In addition, the insertion of the magnet was found to enhance significantly the optical signal in translucent liquids with low bead concentrations but, interesting, not in opaque ones. We believe that this low-cost (less than EURO150) optical immunoassay sensor has potential applications such as detecting progesterone and bacteria levels in milk, water, saliva, urine, and blood.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software T Technology > TL Motor vehicles. Aeronautics. Astronautics R Medicine
Journal or Publication Title:	Proceedings of the Fifth IASTED International Conference on Biomedical Engineering
Publisher:	ACTA PRESS ANAHEIM
ISBN:	978-0-88986-648-5
Editor:	Gardner, JW
Date:	2007
Number of Pages:	6
Page Range:	pp. 277-282
Publication Status:	Published
Title of Event:	5th IASTED International Conference on Biomedical Engineering
Location of Event:	Innsbruck, AUSTRIA
Date(s) of Event:	FEB 14-16, 2007
URI:	http://wrap.warwick.ac.uk/id/eprint/30997

Data sourced from Thomson Reuters' Web of Knowledge

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