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Unsupervised clustering of gene expression time series with conditional random fields

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Yuan, Yinyin and Li, Chang-Tsun (2007) Unsupervised clustering of gene expression time series with conditional random fields. In: IEEE International Conference on Digital Ecosystems and Technologies, Cairns, Australia, 21-23 Feb 2007. Published in: 2007 Inaugural IEEE-IES. Digital EcoSystems and Technologies Conference, pp. 59-64. ISBN 1424404673. doi:10.1109/DEST.2007.372040

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Abstract

A key challenge of gene expression time series research is the development of efficient and reliable probabilistic models. In response, we propose an unsupervised conditional random fields (CRFs) model for gene expression time series clustering. Conditional random fields have demonstrated superior performance over generative models such as hidden Markov models (HMMs) in terms of computational efficiency on many sequence-data-based tasks. Yet their potential has not been previously explored in this field. In the proposed model, time series data are allowed to interact with each other via a voting pool scheme while clusters are progressively formed. Experiments based on both biological data and simulated data verify the suitability of our model to gene expression data analysis via the comparison with a recent work.

Item Type: Conference Item (Paper)
Subjects: Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software
T Technology
Divisions: Faculty of Science, Engineering and Medicine > Science > Computer Science
Series Name: IEEE International Conference on Digital Ecosystems and Technologies
Journal or Publication Title: 2007 Inaugural IEEE-IES. Digital EcoSystems and Technologies Conference,
Publisher: IEEE Computer Society
ISBN: 1424404673
Official Date: 2007
Dates:
DateEvent
2007UNSPECIFIED
Number of Pages: 6
Page Range: pp. 59-64
DOI: 10.1109/DEST.2007.372040
Status: Peer Reviewed
Publication Status: Published
Conference Paper Type: Paper
Title of Event: IEEE International Conference on Digital Ecosystems and Technologies
Type of Event: Conference
Location of Event: Cairns, Australia
Date(s) of Event: 21-23 Feb 2007

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