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Myometrial function in prematurity
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Blanks, Andrew M., Shmygol, Anatoly and Thornton, Steven (2007) Myometrial function in prematurity. Best Practice & Research: Clinical Obstetrics & Gynaecology, Vol.21 (No.5). pp. 807-819. doi:10.1016/j.bpobgyn.2007.03.003
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Official URL: http://dx.doi.org/10.1016/j.bpobgyn.2007.03.003
Abstract
The primary function of the uterus during gestation is to harbour the growing conceptus in a largely quiescent environment. Upon maturation of the fetus to a point sufficient for extrauterine survival, the uterus must remodel itself sufficiently to generate forceful contractions during labour. During preterm delivery, the process of remodelling of the myometrium occurs early due to a number of different causes, although the underlying basis for myometrial contraction remains the same.
This review summarises the anatomical, physiological and molecular basis for contraction. We describe the fibre structure of the human uterus and how this relates to the spread of electrical excitation during a contraction. The process of excitation within a single myometrial cell is described, as well as how this relates to contraction. We then focus on how excitation-contraction coupling is modulated by intercellular communication, pharmacomechanical-coupling and hormonal milieu. Lastly, we consider the actions of the commonly accepted uterine agonists oxytocin, prostaglandin F-2 alpha, and prostaglandin E-2, and the tocolytic ritodrine.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Best Practice & Research: Clinical Obstetrics & Gynaecology | ||||
| Publisher: | Bailliere Tindall | ||||
| ISSN: | 1521-6934 | ||||
| Official Date: | October 2007 | ||||
| Dates: |
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| Volume: | Vol.21 | ||||
| Number: | No.5 | ||||
| Number of Pages: | 13 | ||||
| Page Range: | pp. 807-819 | ||||
| DOI: | 10.1016/j.bpobgyn.2007.03.003 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
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