Raymond, Neil T., Zehnder, Daniel, Smith, Stephen C. H., Stinson, Julie A., Lehnert, Hendrik and Higgins, Robert M.. (2007) Elevated relative mortality risk with mild-to-moderate chronic kidney disease decreases with age. Nephrology Dialysis Transplantation, Vol.22 (No.11). pp. 3214-3220. ISSN 0931-0509

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Abstract

Background. Renal disease is common in the general population and whilst few people progress to end-stage renal failure, mortality is increased. The aim of this study was to examine all-cause mortality risk in relation to chronic kidney disease (CKD) stages defined by estimated glomerular filtration rate (eGFR). Methods. Data were extracted from a computerized central laboratory system for a defined geographical area over a 3-year study period. The eGFR was calculated using the four-variable Modification of Diet in Renal Disease (MDRD) formula and aligned to the MDRD laboratory. Average annual mortality and relative risk (RR) of all-cause mortality was determined and compared for defined age and CKD bands. Results. 106366 participants (55.5 female; 85 White, 13 South Asian, 2 Black and others) were eligible and studied, representing 49 of the Coventry adult population. 12540 (12) of the sample had some evidence of decreased kidney function, with an eGFR 60ml/min/1.73m(2). 7611 (7) participants died and there were significantly elevated risks of mortality with increasing renal dysfunction; RR 4.0, 8.3, 16.2 and 43.5 for eGFR 4559, 3044, 1529 and 15ml/min/1.73m(2), respectively. Within age bands, RRs were statistically significantly raised with CKD progression and within CKD stage, RR of death decreased as age increased. Conclusions. CKD prevalence increased with age and absolute and RR of mortality increased with progression of CKD. People aged over 75 years, with mild-to-moderate renal disease, representing 41 of this age group, have no increased RR of mortality. Further study of CKD and mortality, particularly progression over time and with respect to age is needed.

Item Type:	Journal Article
Subjects:	R Medicine > RD Surgery R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Nephrology Dialysis Transplantation
Publisher:	Oxford University Press
ISSN:	0931-0509
Date:	November 2007
Volume:	Vol.22
Number:	No.11
Number of Pages:	7
Page Range:	pp. 3214-3220
Identification Number:	10.1093/ndt/gfm396
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/31185

Data sourced from Thomson Reuters' Web of Knowledge

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