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Effect of parental smoking on cotinine levels in newborns
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Joseph, D. V., Jackson, J. A., Westaway, J., Taub, N. A., Petersen, S. A. and Wailoo, M. P. (2007) Effect of parental smoking on cotinine levels in newborns. Archives of Disease in Childhood. Fetal and Neonatal Edition, Volume 92 (Number 6). pp. 484-488. doi:10.1136/adc.2006.108506 ISSN 1359-2998.
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Official URL: http://dx.doi.org/10.1136/adc.2006.108506
Abstract
Background: Smoking is a major risk factor for cot death. Many infants smoke passively as a result of parental smoking. This paper reports on infants exposed to a smoking environment and how they accumulate metabolites of cigarette smoke, such as cotinine, which may be physiologically harmful.
Aim: To assess cotinine levels in infants of smoking parents.
Method: Cotinine excretion in urine was assessed in 104 infants, of whom 71 had smoking parents and 33 had non-smoking parents. All cotinine levels were measured at approximately 12 weeks of age. The subjects were selected from a database of infants in developmental physiological studies which assessed the impact of various factors on early postnatal development.
Results: On average babies with at least one parent who was a current cigarette smoker excreted 5.58 (95% Cl 3.4 to 9.5) times as much cotinine in the urine as did the babies of non-smoking parents. Maternal smoking was the largest contributing factor. Co-sleeping (p = 0.037) and the minimum room temperature (p = 0.028) were significant contributory factors.
Conclusion: Infants from smoking households accumulate cotinine, a metabolite of nicotine, which may have a detrimental effect on the cardiorespiratory system.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RJ Pediatrics | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Archives of Disease in Childhood. Fetal and Neonatal Edition | ||||
Publisher: | B M J Group | ||||
ISSN: | 1359-2998 | ||||
Official Date: | November 2007 | ||||
Dates: |
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Volume: | Volume 92 | ||||
Number: | Number 6 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 484-488 | ||||
DOI: | 10.1136/adc.2006.108506 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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