Joseph, D. V., Jackson, J. A., Westaway, J., Taub, N. A., Petersen, S. A. and Wailoo, M. P.. (2007) Effect of parental smoking on cotinine levels in newborns. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 92 (6). pp. 484-488. ISSN 1359-2998

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Abstract

Background: Smoking is a major risk factor for cot death. Many infants smoke passively as a result of parental smoking. This paper reports on infants exposed to a smoking environment and how they accumulate metabolites of cigarette smoke, such as cotinine, which may be physiologically harmful. Aim: To assess cotinine levels in infants of smoking parents. Method: Cotinine excretion in urine was assessed in 104 infants, of whom 71 had smoking parents and 33 had non-smoking parents. All cotinine levels were measured at approximately 12 weeks of age. The subjects were selected from a database of infants in developmental physiological studies which assessed the impact of various factors on early postnatal development. Results: On average babies with at least one parent who was a current cigarette smoker excreted 5.58 (95% Cl 3.4 to 9.5) times as much cotinine in the urine as did the babies of non-smoking parents. Maternal smoking was the largest contributing factor. Co-sleeping (p = 0.037) and the minimum room temperature (p = 0.028) were significant contributory factors. Conclusion: Infants from smoking households accumulate cotinine, a metabolite of nicotine, which may have a detrimental effect on the cardiorespiratory system.

Item Type:	Journal Article
Subjects:	R Medicine > RJ Pediatrics
Journal or Publication Title:	ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
Publisher:	B M J PUBLISHING GROUP
ISSN:	1359-2998
Date:	November 2007
Volume:	92
Number:	6
Number of Pages:	5
Page Range:	pp. 484-488
Identification Number:	10.1136/adc.2006.108506
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/31209

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