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Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy
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Griffin, John M., Martin, Dave R. and Brown, Steven P. (2007) Distinguishing anhydrous and hydrous forms of an active pharmaceutical ingredient in a tablet formulation using solid-state NMR spectroscopy. Angewandte Chemie International Edition, Volume 46 (Number 42). pp. 8036-8038. doi:10.1002/anie.200702582 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.200702582
Abstract
With or without water? In under two hours, an NMR spectroscopy experiment can determine whether the anhydrous form of an active pharmaceutical ingredient is present in a tablet formulation. Such a high-resolution spectrum constitutes a new analytical tool that should be routinely adopted in the characterization of pharmaceuticals.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
Journal or Publication Title: | Angewandte Chemie International Edition | ||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
ISSN: | 1433-7851 | ||||
Official Date: | 2007 | ||||
Dates: |
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Volume: | Volume 46 | ||||
Number: | Number 42 | ||||
Number of Pages: | 3 | ||||
Page Range: | pp. 8036-8038 | ||||
DOI: | 10.1002/anie.200702582 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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