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An investigation into the tether length and substitution pattern of arene-substituted complexes for asymmetric transfer hydrogenation of ketones
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Cheung, Fung Kei, Lin, Changxue, Minissi, Franco, Crivillé, Adriana Lorente, Graham, Mark A., Fox, David J. and Wills, Martin (2007) An investigation into the tether length and substitution pattern of arene-substituted complexes for asymmetric transfer hydrogenation of ketones. Organic Letters, Vol.9 (No.22). pp. 4659-4662. doi:10.1021/ol702226j ISSN 1523-7060.
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Official URL: http://dx.doi.org/10.1021/ol702226j
Abstract
A series of Ru(II) catalysts were prepared and tested in the asymmetric transfer hydrogenation of ketones. The catalyst containing a "4-carbon" tether gave the fastest rates of ketone reduction. This is due to both increased rate of regeneration of hydride "Ru-H" and increased rate of ketone reduction. Several classes of ketone were reduced in enantiomeric excesses of up to 97%. Substituents on the arene ring of the catalyst influence the reaction rate and enantioselectivity.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Organic Letters | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 1523-7060 | ||||
Official Date: | 25 October 2007 | ||||
Dates: |
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Volume: | Vol.9 | ||||
Number: | No.22 | ||||
Number of Pages: | 4 | ||||
Page Range: | pp. 4659-4662 | ||||
DOI: | 10.1021/ol702226j | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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