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Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function
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Rabbani, Naila, Sebekova, K., Sebekova, K., Heidland, A. and Thornalley, Paul J.. (2007) Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function. Kidney International, Vol.72 (No.9). pp. 1113-1121. ISSN 0085-2538
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Official URL: http://dx.doi.org/10.1038/sj.ki.5002513
Abstract
Glycation, oxidation, and nitration of endogenous proteins occur spontaneously and these modifications are also present in foods. Increased levels of these chemical changes are associated with chronic renal failure; however, little is known about acute kidney failure. We measured these modifications of plasma protein and related free adducts in plasma following bilateral nephrectomy and bilateral ureteral obstruction. Advanced glycation end-product (AGE) residues of plasma protein were increased 3 h post-surgery, and thereafter slowly decreased in all groups, reflecting changes in plasma protein synthesis and transcapillary flow post- surgery. Ureteral ligation increased oxidation and nitration adduct residues. There were, however, marked increases in AGE, dityrosine, or 3-nitrotyrosine free adducts in both nephrectomized and ureter-ligated rats compared to rats that had undergone sham operations. There were lower modified adduct concentrations in the ureter-ligated compared to the nephrectomized rats, reflecting residual glomerular filtration and tubular removal. There was no increase in glycated, oxidized, and nitrated proteins. Glyoxal and methylglyoxal were also increased in both renal failure models. Our study shows that the acute loss of renal function and urinary excretion leads to the accumulation of AGE, oxidation, and nitration free adducts in the plasma.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Kidney International |
| Publisher: | Nature Publishing Group |
| ISSN: | 0085-2538 |
| Date: | November 2007 |
| Volume: | Vol.72 |
| Number: | No.9 |
| Number of Pages: | 9 |
| Page Range: | pp. 1113-1121 |
| Identification Number: | 10.1038/sj.ki.5002513 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/31280 |
Data sourced from Thomson Reuters' Web of Knowledge
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