Howard, Laura, Rex, Maria, Clements, Debbie and Woodland, Hugh R.. (2007) Regulation of the Xenopus Xsox17 alpha(1) promoter by co-operating VegT and Sox17 sites. Developmental Biology, Vol.310 (No.2). pp. 402-415. ISSN 0012-1606

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Abstract

The gene encoding the Sox F-group transcription factor Xsox17 alpha(1) is specifically expressed throughout the entire region of the Xenopus blastula fated to become endoderm, and is important in controlling endodermal development. Xsox17 alpha(1) is a direct target of the maternal endodermal determinant VegTand of Sox17 itself We have analysed the promoter of the Xenopus laevis Xsox17 alpha(1) gene by transgenesis, and have identified two important control elements which reside about 9 kb upstream at the start of transcription. These elements individually drive transgenic endodermal expression in the blastula and gastrula. One contains functional, cooperating VegT and Sox-binding consensus sites. The Sox sites in this region are occupied in vivo. The other responds to TGF-beta signals like Activin or Nodals that act through Smad2/3. We propose that these two regions co-operate in regulating the early endodermal expression of the Xsox17 alpha(1) gene.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title:	Developmental Biology
Publisher:	Academic Press
ISSN:	0012-1606
Date:	15 October 2007
Volume:	Vol.310
Number:	No.2
Number of Pages:	14
Page Range:	pp. 402-415
Identification Number:	10.1016/j.ydbio.2007.07.028
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	BBSRC, Wellcome Trust
URI:	http://wrap.warwick.ac.uk/id/eprint/31329

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