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Role of the calcium store in uterine contractility
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Wray, Susan and Shmygol, Anatoly (2007) Role of the calcium store in uterine contractility. Seminars in Cell and Developmental Biology, Vol.18 (No.3). pp. 315-320. ISSN 1084-9521
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2007.05.005
Abstract
This article assesses the nature of the sarcoplasmic reticulum (SR) in uterine smooth muscle. Modern imagining techniques have revealed new information about the location and density of Ca storage and release. Release mechanisms, including IP3 and Ca itself, via ryanodine receptors (RyR), as well as possible roles for cyclic ADP ribose, and the contribution of the SR to relaxation are detailed. The role of the SR Ca-ATPase in both decay of the Ca transient and maintaining Ca homeostasis is reviewed. Recent data on the role of local Ca signals from the SR in contributing to membrane excitability and contractility are discussed, along with interactions with ion channels in lipid microdomains. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Item |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) |
| Journal or Publication Title: | Seminars in Cell and Developmental Biology |
| Publisher: | Elsevier Science Ltd. / Academic Press Ltd. |
| ISSN: | 1084-9521 |
| Date: | June 2007 |
| Volume: | Vol.18 |
| Number: | No.3 |
| Number of Pages: | 6 |
| Page Range: | pp. 315-320 |
| Identification Number: | 10.1016/j.semcdb.2007.05.005 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/31493 |
Data sourced from Thomson Reuters' Web of Knowledge
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