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Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae

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Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2007) Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16). pp. 4654-4656. doi:10.1016/j.bmcl.2007.05.071

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Official URL: http://dx.doi.org/10.1016/j.bmcl.2007.05.071

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Abstract

Adenosine and 2 '-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in Gram-positive bacteria. (c) 2007 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Faculty of Science > Chemistry
Journal or Publication Title: Bioorganic & Medicinal Chemistry Letters
Publisher: Pergamon-Elsevier Science Ltd.
ISSN: 0960-894X
Official Date: 15 August 2007
Dates:
DateEvent
15 August 2007Published
Volume: Vol.17
Number: No.16
Number of Pages: 3
Page Range: pp. 4654-4656
DOI: 10.1016/j.bmcl.2007.05.071
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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