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Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae
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Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G. and Bugg, Tim. (2007) Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16). pp. 4654-4656. ISSN 0960-894X
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Official URL: http://dx.doi.org/10.1016/j.bmcl.2007.05.071
Abstract
Adenosine and 2 '-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in Gram-positive bacteria. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science > Chemistry |
| Journal or Publication Title: | Bioorganic & Medicinal Chemistry Letters |
| Publisher: | Pergamon-Elsevier Science Ltd. |
| ISSN: | 0960-894X |
| Date: | 15 August 2007 |
| Volume: | Vol.17 |
| Number: | No.16 |
| Number of Pages: | 3 |
| Page Range: | pp. 4654-4656 |
| Identification Number: | 10.1016/j.bmcl.2007.05.071 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | http://wrap.warwick.ac.uk/id/eprint/31630 |
Data sourced from Thomson Reuters' Web of Knowledge
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