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Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae
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Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2007) Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16). pp. 4654-4656. doi:10.1016/j.bmcl.2007.05.071 ISSN 0960-894X.
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Official URL: http://dx.doi.org/10.1016/j.bmcl.2007.05.071
Abstract
Adenosine and 2 '-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in Gram-positive bacteria. (c) 2007 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Chemistry |
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| Journal or Publication Title: | Bioorganic & Medicinal Chemistry Letters | ||||
| Publisher: | Pergamon-Elsevier Science Ltd. | ||||
| ISSN: | 0960-894X | ||||
| Official Date: | 15 August 2007 | ||||
| Dates: |
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| Volume: | Vol.17 | ||||
| Number: | No.16 | ||||
| Number of Pages: | 3 | ||||
| Page Range: | pp. 4654-4656 | ||||
| DOI: | 10.1016/j.bmcl.2007.05.071 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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