Shmygol, Anatoly, Blanks, Andrew M., Bru-Mercier, Gilles, Gullam, Joana E. and Thornton, Steven (2007) Control of uterine Ca2+ by membrane voltage toward understanding the excitation-contraction coupling in human myometrium. In: 5th World Congress of Biomechanics, Munich, GERMANY, JUL 29-AUG 04, 2006. Published in: REPRODUCTIVE BIOMECHANICS, 1101 pp. 97-109.

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Abstract

Myometrial contractility is a complex and dynamic physiological process that changes substantially during pregnancy and culminates in childbirth. Uterine contractions are initiated by transient rises in cytoplasmic Ca2+ concentration ([Ca2+](i)),which in turn are triggered and controlled by myometrial action potentials. The sequence of events between the action potential generation and the contraction initiation is referred to as excitation-contraction coupling. Hormones and other physiologically active substances affect myometrial contractility by modulating different steps in the excitation-con traction coupling process. It is therefore imperative that we understand that process to understand the regulation of myometrial contractility. The complex action potentials generated by human myometrium result from the activity of many ion channels, transporters, and pumps. Two types of myometrial action potential waveform have been described in the literature: a plateau type and a spike type. Parameters of the myometrial [Ca2+](i) transients and contractions differ depending on the type of action potential that triggers them. Some aspects of the excitation-contraction coupling are unique to human myometrium and cannot be found in animal models; some others are common between many species. This article reviews the current state and discusses future directions of physiological research on human myometrial excitation-contraction coupling.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	Q Science
Series Name:	ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Journal or Publication Title:	REPRODUCTIVE BIOMECHANICS
Publisher:	BLACKWELL PUBLISHING
ISBN:	978-1-57331-673-6
ISSN:	0077-8923
Editor:	Elad, D and Young, RC
Date:	2007
Volume:	1101
Number of Pages:	13
Page Range:	pp. 97-109
Identification Number:	10.1196/annals.1389.031
Publication Status:	Published
Title of Event:	5th World Congress of Biomechanics
Location of Event:	Munich, GERMANY
Date(s) of Event:	JUL 29-AUG 04, 2006
URI:	http://wrap.warwick.ac.uk/id/eprint/31659

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