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C1q binding and complement activation by prions and amyloids
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Sim, Robert B., Kishore, Uday, Villiers, Christian L., Marche, Patrice N. and Mitchell, Daniel A. (2007) C1q binding and complement activation by prions and amyloids. In: 6th International Workshop on the First Component of Complement C1 and Collectins, Seeheim, Germany, Jun 2006. Published in: Immunobiology, Volume 212 (Number 4-5). pp. 355-362. doi:10.1016/j.imbio.2007.04.001 ISSN 0171-2985.
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Official URL: http://dx.doi.org/10.1016/j.imbio.2007.04.001
Abstract
Clq binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. Clq binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology of several amyloid diseases, such as Alzheimer's disease. Prion diseases, such as scrapie also involve formation of amyloid by polymerization of the host prion protein (PrP). Complement activation is likely to contribute to neuronal damage in the end stages of prion diseases, but is also thought to participate in the initial infection, dissemination and replication stages. Infectious prion particles are likely to bind Clq and activate the complement system. Bound complement proteins may then influence the uptake and transport of prion particles by dendritic cells (DCs) and their subsequent proliferation at sites such as follicular DCs. (c) 2007 Elsevier GmbH. All rights reserved.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR180 Immunology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
| Journal or Publication Title: | Immunobiology | ||||
| Publisher: | Elsevier | ||||
| ISSN: | 0171-2985 | ||||
| Official Date: | 2007 | ||||
| Dates: |
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| Volume: | Volume 212 | ||||
| Number: | Number 4-5 | ||||
| Number of Pages: | 8 | ||||
| Page Range: | pp. 355-362 | ||||
| DOI: | 10.1016/j.imbio.2007.04.001 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 6th International Workshop on the First Component of Complement C1 and Collectins | ||||
| Type of Event: | Workshop | ||||
| Location of Event: | Seeheim, Germany | ||||
| Date(s) of Event: | Jun 2006 |
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