Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes
Ceriello, Antonio, Piconi, Ludovica, Esposito, Katherine and Giugliano, Dario. (2007) Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes. Diabetes Care, Vol.30 (No.7). pp. 1694-1698. ISSN 0149-5992Full text not available from this repository.
Official URL: http://dx.doi.org/10.2337/dc07-0318
OBJECTIVE - Long-lasting hyperglycemia in type I diabetic patients induces permanent alterations of endothelial function by increased oxidative stress, even when glycemia is normalized.
RESEARCH DESIGN AND METHODS - in this study, 36 type I diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided into three groups. The first group was treated for 24 h with insulin, achieving a near normalization of glycemia. After 12 h of this treatment, vitamin C was added for the remaining 12 h. The second group was treated for 24 h with vitamin C. After 12 h of this treatment, insulin was started, achieving a near normalization of glycemia for the remaining 12 h. The third group was treated for 24 h with both vitamin C and insulin, achieving near normalization of glycemia. The same protocols were performed after I month of telmisartan or placebo.
RESULTS - Neither normalization of glycemia nor vitamin C treatment alone was able to normalize endothelial dysfunction or oxidative stress. Combining insulin and vitamin C normalized endothelial dysfunction and decreased oxidative stress to normal levels. Telmisartan significantly improved basal endothelial function and decreased nitrotyrosine plasma levels. In patients treated with telmisartan, a near normalization of both flow-mediated vasodilation and oxidative stress was achieved when glycemia was normalized, whereas adding vitamin C infusion did not show further effect on endothelial function or nitrotyrosine plasma levels.
CONCLUSIONS - These data indicate that combining the normalization of glycemia with an antioxidant can normalize endothelial function in type I diabetic patients and that telmisartan works as an antioxidant like vitamin C.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Journal or Publication Title:||Diabetes Care|
|Publisher:||American Diabetes Association|
|Official Date:||July 2007|
|Number of Pages:||5|
|Page Range:||pp. 1694-1698|
|Access rights to Published version:||Restricted or Subscription Access|
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