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Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes
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Ceriello, Antonio, Piconi, Ludovica, Esposito, Katherine and Giugliano, Dario (2007) Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes. Diabetes Care, Vol.30 (No.7). pp. 1694-1698. doi:10.2337/dc07-0318 ISSN 0149-5992.
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Official URL: http://dx.doi.org/10.2337/dc07-0318
Abstract
OBJECTIVE - Long-lasting hyperglycemia in type I diabetic patients induces permanent alterations of endothelial function by increased oxidative stress, even when glycemia is normalized.
RESEARCH DESIGN AND METHODS - in this study, 36 type I diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided into three groups. The first group was treated for 24 h with insulin, achieving a near normalization of glycemia. After 12 h of this treatment, vitamin C was added for the remaining 12 h. The second group was treated for 24 h with vitamin C. After 12 h of this treatment, insulin was started, achieving a near normalization of glycemia for the remaining 12 h. The third group was treated for 24 h with both vitamin C and insulin, achieving near normalization of glycemia. The same protocols were performed after I month of telmisartan or placebo.
RESULTS - Neither normalization of glycemia nor vitamin C treatment alone was able to normalize endothelial dysfunction or oxidative stress. Combining insulin and vitamin C normalized endothelial dysfunction and decreased oxidative stress to normal levels. Telmisartan significantly improved basal endothelial function and decreased nitrotyrosine plasma levels. In patients treated with telmisartan, a near normalization of both flow-mediated vasodilation and oxidative stress was achieved when glycemia was normalized, whereas adding vitamin C infusion did not show further effect on endothelial function or nitrotyrosine plasma levels.
CONCLUSIONS - These data indicate that combining the normalization of glycemia with an antioxidant can normalize endothelial function in type I diabetic patients and that telmisartan works as an antioxidant like vitamin C.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Diabetes Care | ||||
Publisher: | American Diabetes Association | ||||
ISSN: | 0149-5992 | ||||
Official Date: | July 2007 | ||||
Dates: |
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Volume: | Vol.30 | ||||
Number: | No.7 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 1694-1698 | ||||
DOI: | 10.2337/dc07-0318 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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